During liver transplantation (LT) the glucose metabolism is effected by a crucial disturbance. The blood glucose level is extremely hard to control by conventional clinical protocols during this phase. Model based approach can enhance the blood glucose control during the anhepatic phase (absence of liver) and post-anhepatic phase. The physiological constants of validated clinical metabolic model were slightly modified based on previous studies. The model fitting errors and the sufficient capture of the blood glucose (BG) dynamic evinced the applicability of the model. However the sufficient per-patient estimation of endogenous production could more enhance the performance of the model based BG prediction. © 2013 IEEE.