Alice Cattelani
57720010400
Publications - 1
Clinical and Financial Validation of the International Study Group for Pancreatic Surgery (ISGPS) Definition of Post-Pancreatectomy Acute Pancreatitis (PPAP): International Multicenter Prospective Study
Oliver Strobel
Jens Werner
Christopher L. Wolfgang
Giovanni Marchegiani
Mustapha Adham
Maximillian Bockhorn
Ugo Boggi
Olivier R.C. Busch
Kevin Christopher Conlon
Abe Fingerhut
Helmut Friess
Giuseppe Kito Fusai
Werner Hartwig
Charles Vollmer
Nicholas J. Zyromski
Asahi Sato
Daniel Kilburn
Keith D. Lillemoe
Alberto Manzoni
Dejan Radenkovic
Michael Sarr
Kyoichi Takaori
Markus W. Büchler
Marc G. Besselink
Cristina Ferrone
Thilo Hackert
Roberto Salvia
Yi Miao
Massimo Falconi
Christos Dervenis
John P. Neoptolemos
Shailesh V. Shrikhande
Elisa Bannone
Alice Cattelani
Gaetano Corvino
Alessio Marchetti
Valentina Andreasi
Giuseppe Malleo
Manish Bhandare
Kaival Gundavda
Nicolò Pecorelli
Domenico Tamburrino
Alessandro Esposito
Francesca Fermi
Kuirong Jiang
Zipeng Lu
Stefano Partelli
Jie Yin
Harish Lavu
Rosa Klotz
Daniela Merz
Christoph Michalski
Ulla Klaiber
Marco Montorsi
Gennaro Nappo
Naoki Ikenaga
Pasquale Scornamiglio
Bodil Andersson
Fraser Jeffery
Daniel Halloran
Robert Padbury
Ajith K. Siriwardena
Savio George Barreto
Luca Gianotti
Christopher M. Halloran
Saxon Connor
Roland Andersson
Jakob R. Izbicki
Masafumi Nakamura
Alessandro Zerbi
Mohammad Abu Hilal
Martin Loos
Charles J. Yeo
Attila Oláh
Publication Name: Annals of Surgery
Publication Date: 2024-01-01
Volume: Unknown
Issue: Unknown
Page Range: Unknown
Description:
Objective: To validate the ISGPS definition and grading system of PPAP after pancreatoduodenectomy (PD). Summary Background Data: In 2022, the International Study Group for Pancreatic Surgery (ISGPS) defined post-pancreatectomy acute pancreatitis (PPAP) and recommended a prospective validation of its diagnostic criteria and grading system. Methods: This was a prospective, international, multicenter study including patients undergoing PD at 17 referral pancreatic centers across Europe, Asia, Oceania, and the United States. PPAP diagnosis required the following three parameters: (1) postoperative serum hyperamylasemia /hyperlipasemia (POH) persisting on postoperative days 1 and 2, (2) radiologic alterations consistent with PPAP, and (3) a clinically relevant deterioration in the patient's condition. To validate the grading system, clinical and economic parameters were analyzed across all grades. Results: Among 2902 patients undergoing PD, 7.5% (n=218) developed PPAP (6.3% grade B and 1.2% grade C). POH occurred in 24.1% of patients. Hospital stay was associated with PPAP grades (No POH/PPAP 10 days (IQR 7-17) days, grade B 22 days (IQR 15-34) days, and grade C 43 days (IQR 27-54) days; P<0.001), as well as intensive care unit admission (No POH/PPAP 5.4%, grade B 12.6%, grade C 82.9%; P<0.010), and hospital readmission rates (No POH/PPAP 7.3%, grade B 16.1%, grade C 18.5%; P<0.05). Costs of grade B and C PPAP were 2 and 11 times greater than uncomplicated clinical course, resp. (P<0.001). Conclusions: This first prospective, international validation study of the ISGPS definition and grading system for PPAP highlighted the relevant clinical and financial implications of this condition. These results stress the importance of routine screening for PPAP in patients undergoing PD.
Open Access: Yes
