Angled guide plates are used to transmit the forces induced by trains, from the rail seat, to the concrete sleepers. Additionally, the design of the angled guide plates, with an appropriate width, supports tilting protection. Considering the updated requirements of the ML-1 railway line, in the Islamic Republic of Pakistan, an optimization design of the angled guide plate of the Vossloh W14-PK fasteners was carried out herein. The design requirements of the angled guide plate need to meet the requirements of structural stress and protect the plates from deterioration. Given the conducted refined model of the Vossloh W14-PK fastener, it is shown that the force and deformation of the angled guide plate, in the bearing groove adjacent and the outside bolt hole area, are small. Therefore, it was preliminarily recommended that the optimization area of the angled guide plate be divided into the section I, close to the rail groove and section II, outside the bolt hole. The Finite Element Model (FEM) of angled guide plate was established, which is used to analyze the influences of length, width, depth and the number of holes, in section I and section II, on the force distribution, across the angled guide plate. The results show that the scheme of reducing the amount of material and minimizing the influence of force on the structure of the angled guide plate, is to punch three holes in section I and two holes in section II. The holes in section I/II are 20/30 mm in length, 8/8 in width, and 15/8 mm in depth, respectively. The fatigue test showed that the optimized angled guide plate, had good application effects.