Background: Perfectionism is a multidimensional construct characterized by the striving for exceptionally high standards and critical self-evaluation. It can manifest in both adaptive and maladaptive forms. Feedback systems exert a considerable cognitive influence on individuals as the emotional and behavioral responses to feedback are often shaped by its valence—positive or negative. This study aimed to examine the relationship between feedback systems and perfectionism, including its various dimensions, and to assess how specific interventions influence perfectionistic traits. Methods: A systematic literature review was conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines across six academic databases: PubMed, PsycINFO, Scopus, ScienceDirect, EBSCO, and ERIC. The initial search yielded 441 articles. After applying the inclusion and exclusion criteria, 24 studies were selected for detailed analysis. Results: A clear association emerged between feedback valence and perfectionism. Four major outcome domains were identified as dependent variables: emotional response, behavior, task performance, and physiological (biomarker) indicators. Among adaptive perfectionists, positive feedback was linked to improved behavioral outcomes, whereas negative feedback elicited negative emotional and performance-related consequences. In contrast, maladaptive perfectionists showed a heightened vulnerability to negative feedback, displaying impaired emotional regulation, decreased performance, and elevated stress-related physiological markers. Conclusion: Feedback directed at individuals with perfectionistic traits elicits distinct psychological and physiological responses. While positive feedback can foster beneficial outcomes in adaptive perfectionists, negative feedback—especially in maladaptive perfectionists—can have substantial adverse effects, highlighting the importance of developing individualized feedback strategies as part of the clinical and therapeutic interventions for individuals with perfectionistic vulnerability. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD420251015998.