Zoltán Benyó

7003461451

Publications - 7

Robust blood-glucose control using Mathematica

Balázs Benyó László Török L. Kovács Zoltán Benyó B. Paláncz

Publication Name: Annual International Conference of the IEEE Engineering in Medicine and Biology Proceedings

Publication Date: 2006-12-01

Volume: Unknown

Issue: Unknown

Page Range: 451-454

Description:

A robust control design on frequency domain using Mathematica is presented for regularization of glucose level in Type I diabetes persons under intensive care. The method originally proposed under Mathematica by Helton and Merino, [1] - now with an improved disturbance rejection constraint inequality - is employed, using the three-state minimal patient model of [2]. The robustness of the resulted high-order linear controller is demonstrated by nonlinear closed loop simulation in state-space, in case of standard meal disturbances and is compared with H∞ design implemented with the mu-toolbox of Matlab. The controller designed with model parameters represented the most favorable plant dynamics from the point of view of control purposes, can operate properly even in case of parameter values of the worst-case scenario. ©2006 IEEE.

Open Access: Yes

DOI: 10.1109/IEMBS.2006.259916

In search of the nature of specific nucleic acid-protein interactions

Balázs Benyó J. C. Biro Zoltán Benyó C. Sansom

Publication Name: Acta Physiologica Hungarica

Publication Date: 2005-06-23

Volume: 92

Issue: 1

Page Range: 1-10

Description:

The theory of "codon-amino acid coevolution" was first proposed by Woese in 1967. It suggests that there is a stereochemical matching - that is, affinity - between amino acids and certain of the base triplet sequences that code for those amino acids. We have constructed a Common Periodic Table of Codons and Amino Acids, where the Nucleic Acid Table showed perfect axial symmetry for codons and the corresponding Amino Acid Table also displayed periodicity regarding the biochemical properties (charge and hydrophobicity) of the 20 amino acids and the position of the stop signals. The Table indicates that the middle (2nd) amino acid in the codon has a prominent role in determining some of the structural features of the amino acids. The possibility that physical contact between codons and amino acids might exist was tested on restriction enzymes. Many recognition site-like sequences were found in the coding sequences of these enzymes and as many as 73 examples of codon-amino acid co-location were observed in the 7 known 3D structures (December 2003) of endonuclease-nucleic acid complexes. These results indicate that the smallest possible units of specific nucleic acid-protein interaction are indeed the stereochemically compatible codons and amino acids. © 2005 Akadémiai Kiadó.

Open Access: Yes

DOI: 10.1556/APhysiol.92.2005.1.1

Codes in the codons: Construction of a codon/amino acid periodic table and a study of the nature of specific nucleic acid - Protein interactions

Balázs Benyó J. C. Biro Zoltán Benyó

Publication Name: Annual International Conference of the IEEE Engineering in Medicine and Biology Proceedings

Publication Date: 2004-12-01

Volume: 26 IV

Issue: Unknown

Page Range: 2860-2863

Description:

The theory of "codon-amino acid coevolution" was first proposed by Woese in 1967. It suggests that there is a stereochemical matching - that is, affinity - between amino acids and certain of the base triplet sequences that code for those amino acids. We have constructed a Common Periodic Table of Codons and Amino Acids, where the Nucleic Acid Table showed perfect axial symmetry for codons and the corresponding Amino Acid Table also displayed periodicity regarding the biochemical properties (charge and hydrophobicity) of the 20 amino acids and the position of the stop signals. The Table indicates that the middle (2nd) amino acid in the codon has a prominent role in determining some of the structural features of the amino acids. The possibility that physical contact between codons and amino acids might exist was tested on restriction enzymes. Many recognition site-like sequences were found in the coding sequences of these enzymes and as many as 73 examples of codon - amino acid co-location were observed in the 7 known 3D structures (December 2003) of endonuclease-nucleic acid complexes. These results indicate that the smallest possible units of specific nucleic acid - protein interaction are indeed the stereochemically compatible codons and amino acids.

Open Access: Yes

DOI: DOI not available

A fully symbolic design and modeling of nonlinear glucose control with Control System Professional Suite (CSPS) of Mathematica

Balázs Benyó L. Kovács Zoltán Benyó B. Paláncz

Publication Name: Acta Physiologica Hungarica

Publication Date: 2004-09-09

Volume: 91

Issue: 2

Page Range: 147-156

Description:

In this case study a fully symbolic design and modeling method are presented for blood glucose control of diabetic patients under intensive care using Mathematica. The analysis is based on a modified two-compartment model proposed by Bergman et al. (2). The applied feedback control law decoupling even the nonlinear model leads to a fully symbolic solution of the closed loop equations. The effectivity of the applied symbolic procedures being mostly built-in the new version of Control System Professional Suite (CSPS) Application of Mathematica have been demonstrated for controller design in case of a glucose control for treatment of diabetes mellitus and also presented for a numerical situation described in Juhász (8). The results are in good agreement with the earlier presented symbolic-numeric analysis by Benyó et al. (1).

Open Access: Yes

DOI: 10.1556/APhysiol.91.2004.2.6

Biomedical Engineering Education and Related Research Activity in Hungary

Balázs Benyó P. Somogyi L. Kovács L. Szilágyi Zoltán Benyó Péter Várady

Publication Name: Annual International Conference of the IEEE Engineering in Medicine and Biology Proceedings

Publication Date: 2003-12-01

Volume: 4

Issue: Unknown

Page Range: 3533-3535

Description:

Biomedical Engineering is a relatively new interdisciplinary science. This paper presents the biomedical engineering activity, which is carried out at Budapest University of Technology and Economics and its partner institutes. In the first part the main goals and the curriculum of the Biomedical Engineering ducation Program (BMEEP) is presented. The second part of the paper summarizes the most important biomedical engineering researches carried out mostly in the Biomedical Engineering Laboratory of our university.

Open Access: Yes

DOI: DOI not available

A common periodic table of codons and amino acids

Balázs Benyó G. Fördös J. C. Biro Á Szlávecz T. Micsik Zoltán Benyó C. Sansom

Publication Name: Biochemical and Biophysical Research Communications

Publication Date: 2003-06-27

Volume: 306

Issue: 2

Page Range: 408-415

Description:

A periodic table of codons has been designed where the codons are in regular locations. The table has four fields (16 places in each) one with each of the four nucleotides (A, U, G, C) in the central codon position. Thus, AAA (lysine), UUU (phenylalanine), GGG (glycine), and CCC (proline) were placed into the corners of the fields as the main codons (and amino acids) of the fields. They were connected to each other by six axes. The resulting nucleic acid periodic table showed perfect axial symmetry for codons. The corresponding amino acid table also displaced periodicity regarding the biochemical properties (charge and hydropathy) of the 20 amino acids and the position of the stop signals. The table emphasizes the importance of the central nucleotide in the codons and predicts that purines control the charge while pyrimidines determine the polarity of the amino acids. This prediction was experimentally tested. © 2003 Elsevier Science (USA). All rights reserved.

Open Access: Yes

DOI: 10.1016/S0006-291X(03)00974-4

An open architecture patient monitoring system using standard technologies

Balázs Benyó Zoltán Benyó Péter Várady

Publication Name: IEEE Transactions on Information Technology in Biomedicine

Publication Date: 2002-03-01

Volume: 6

Issue: 1

Page Range: 95-98

Description:

Computer-aided bedside patient monitoring is applied in areas where real-time vital function analysis takes place. Modern bedside monitoring requires not only the networking of bedside monitors with a central monitor but also other standard communication interfaces. In this paper, a novel approach to patient monitoring is introduced. A patient monitoring system was developed and implemented based on an existing industry standard communication network, using standard hardware components and software technologies. The open architecture system design offers scalability, standard interfaces, and flexible signal interpretation possibilities.

Open Access: Yes

DOI: 10.1109/4233.992168