In this chapter, the authors present a novel technique to analyze the role of subjective factors such as innovations in the economy that influence the design of reusable packaging systems in a given industrial region. The focus of this chapter is on the power of innovation, which is not a directly measurable unit. Nowadays, with modern supply chains, companies and packaging engineers have to determine what constitutes adequate packaging with optimal waste. These decisions are usually based on known data and information, but the goal now is to create packaging that has a more favorable environmental impact than before. It seems obvious that more advanced regions will create more advanced packaging systems, but either way having an innovative milieu is a necessary prerequisite of this. This chapter shows that a willingness to innovate is an indispensable requirement of the design of advanced packaging and that most of the time this depends on the synergic effect of local production factors and regional peculiarities.