Background and Aims: The biopsychosocial (BPS) model considers that health and behavioral outcomes result from the interaction of biological, psychological, and social factors. Regular exercise is an essential component of modern-day healthy living. All three factors in the BPS model are related to long-term exercise. Therefore, this cross-sectional study aimed to compare adults exercising regularly for at least 3 years with their non-exercising counterparts on perceived health and stress (antagonistic, biopsychological), life satisfaction (psychological), and perceived income (psychosocial) while controlling for age, gender, and education level. Methods: Participants were 461 Hungarian volunteers (74.83% female) aged 18−73 years. There were 274 regular exercisers and 187 non-exercisers. They completed the study on the Qualtrics research platform. Results: A statistically significant (p < 0.001) multivariate analysis of covariance revealed that long-term exercisers scored lower on perceived stress and higher on perceived health, income, and life satisfaction than non-exercising adults. Consequently, the three factors of the BPS model differentiated the groups. Still, the effect sizes were relatively small. Finally, perceived stress was a statistically significant (p < 0.001) mediator of life satisfaction. Conclusion: These findings support the idea that long-term exercise behavior can be studied via the BPS model and the role of stress in life satisfaction. The results have practical implications for promoting a healthy and satisfactory life targeting multi-level development through exercise based on the BPS model.