The Traveling Salesman Problem (TSP) is an NP-hard graph search problem. Despite having numerous modifications of the original abstract problem, Time Dependent Traveling Salesman Problem (TD TSP) was one of the most realistic extensions under real traffic conditions. In TD TSP the edges between nodes are assigned higher costs (weights), if they were traveled during the rush hour periods, or crossed the traffic jam regions, such as the city center(s). In this paper we introduce an even more real-life motivated approach, the Intuitionistic Fuzzy Time Dependent Traveling Salesman Problem (IFTD TSP), which is a further extension of the TSP, and also of the classic TD TSP, with the additional notion of using intuitionistic fuzzy sets for the definition of uncertain costs, time, and space of the rush hour—traffic jam region affecting graph sections. In IFTD TSP we use fuzzy memberships and non-memberships sets for estimating the vague costs between nodes in order to quantify the behavior of traffic jam regions, and the rush hour periods. Since intuitionistic fuzzy sets are generalizations of classic fuzzy sets, our approach may be considered an extension and substitution of the original abstract TD TSP problem, even, of the (classic) Fuzzy TD TSP. Lastly, DBMEA (Discrete Bacterial Memetic Evolutionary Algorithm) was applied on the IFTD TSP model, the results of the simulation runs based on some extensions of the benchmarks generated from the original TD TSP data set showed quite good and promising preliminary results.