The otitis media is one of the mostly existing illness for the children, therefore investigation of the human middle ear ventilation is an actual problem. In earlier investigations both experimental and theoretical approach one can find in ([1]-[3]). Here we give a new mathematical and computer model to simulate this ventilation process. This model able to describe the diffusion and flow processes simultaneously, therefore it gives more precise results than earlier models did. The article contains the mathematical model and some results of the simulation. © 2008 American Institute of Physics.