A compound is oestrogenic, when -even if with low affinity but can bind to oestrogen receptors (ER)- resulting in a biological effect in oestrogen sensitive cells, which are similar to processes caused by the ovarian derived oestrogen hormones. According to literature data, due to slurry irrigation and intensive livestock manure application, due to the direct contact with the land, steroidal oestrogens, including oestrogen E1, oestradiol E2, oestriol E3, and synthetic oestrogen EE2 are ubiquitous in the fertile soil. Plants can accumulate oestrogens in their roots and shoots, which when entering the food chain may have an impact on human health. Slurry can only be applied to agricultural land with the permission of the soil protection authority, which also determines the amount of slurry that can be applied to the area. The different types of slurry differ not only in their nutrient composition but also in their EDC content. Regarding the natural hormone excretion and use of hormonal preparations it is important to consider the sex ratio and age range of livestock in the case of selection. It is important for the future that we carry out toxicological studies and place greater emphasis on the amount and potential effects of hormonal substances released by agricultural side products.