Objective: The study aimed to assess the physical and mental health status of active ambulance workers concerning the additional workload they are facing due to the coronavirus pandemic. Data and methods: A cross-sectional survey was conducted with 130 Hungarian National Ambulance Service em¬ployees (n = 130) in the first quarter of 2023, using an online questionnaire on a voluntary, anonymous basis. After convenience sampling, physical and mental health were assessed using the SF-36 questionnaire, along with questions on musculoskeletal status and experience of the COVID-19 pandemic. SPSS was used for data analysis, with descrip¬tive and mathematical statistical tests. The results were significant at p<0.05. Results: The ambulance workers considered their "Physical functioning"to be the best (mean 90.7 ± 13.2 points) and their "General health"to be the worst (55.4 ± 9.5 points). The dimensions were correlated (p<0.001). 73.1% of the sample had a musculoskeletal complaint in the last 5 years, with the highest proportions in the back area (56.8%) and spine (51.5%). These ambulance workers rated their "Physical Functioning"significantly worse (p = 0.002). 95 persons were registered as COVID-19-infected, 50% of whom were only slightly or not at all affected by the pandemic (mean 2.6 ± 1.2). The experience of the coronavirus had a negative impact on the dimensions "Vitality"(r = -0.204, p = 0.020), "Emotional role"(r = -0.317, p<0.001) and "Mental health"(r = -0.283, p = 0.001). Persons with residual symptoms of COVID-19 rated their "Physical functioning"(p = 0.015), "Physical pain"(p = 0.010), "Social functioning"(p = 0.001), and "Mental health"(p = 0.023) dimensions worse. Conclusion: The sudden increase in workload caused by the pandemic makes it essential to monitor ambulance work¬ers' health closely. Residual symptoms of the coronavirus and concomitant musculoskeletal disorders can compro¬mise the quality of patient care.