Monoculture involves growing the same crop on the same land over at least two crop cycles. Continuous monoculture can increase the population density of pests and pathogens over time, thereby reducing agricultural yields and increasing dependence on chemical inputs. Crop rotation is an agricultural practice that involves systematically and sequentially planting different crops in the same field over multiple growing seasons. This review explores the advantages of crop rotation and its contribution to promoting sustainable farming practices, such as legume integration and cover cropping. It is based on a thematic literature review of peer-reviewed studies published between 1984 and 2025. We found that crop rotation can significantly improve soil structure and organic matter content and enhance nutrient cycling. Furthermore, soil organic carbon increased by up to 18% when legumes were included in rotations compared to monoculture systems in Europe, while also mitigating greenhouse gas emissions, enhancing carbon sequestration, and decreasing nutrient leaching and pesticide runoff. Farmers can adopt several strategies to optimise crop rotation benefits, such as diversification of various crops, legume integration, cultivation of cover crops, and rotational grazing. These practices ensure agricultural sustainability and food security and support climate resilience.