HPWS is currently perceived as potential source of the competitive skills, capabilities and knowledge of human resources. This study aim to illustrate how high-performance work systems (HPWS) offer the foundation for strategic business performance (SBP) through the mediating function of organizational flexibility and contextualizing manufacturing firms of developing countries by providing an empirically tested framework for analyzing SBP. The current study is based on a quantitative research design. Data were gathered from manufacturing firms from the top, middle and operational management firms. SEM was used to analyze our 589 samples. Findings revealed that HPWS is the only component aiding manufacturing firms’ growth. The results illustrate that HPWS will take a long time to achieve SBP if organisational flexibility does not mediate the relationship between HPWS and SBP. Utilizing actual data, this study reveals practical strategies for enhancing the mechanism of business development performance among manufacturing organizations. Furthermore, this research helps to understand the relationship between HPWS and organizational flexibility in attaining SBP.