This paper deals with the flow shop scheduling problem. To find the optimal solution is an NP-hard problem. The paper reviews some algorithms from the literature and applies a benchmark dataset to evaluate their efficiency. In this research work, the discrete bacterial memetic evolutionary algorithm (DBMEA) as a global searcher was investigated. The proposed algorithm improves the local search by applying the simulated annealing algorithm (SA). This paper presents the experimental results of solving the no-idle flow shop scheduling problem. To compare the proposed algorithm with other researchers’ work, a benchmark problem set was used. The calculated makespan times were compared against the best-known solutions in the literature. The proposed hybrid algorithm has provided better results than methods using genetic algorithm variants, thus it is a major improvement for the memetic algorithm family solving production scheduling problems.