In the last decade, ICT has significantly impacted economic growth in many developing countries, such as Kazakhstan. In addition, there is practically no analysis of the level of interconnections between the communication infrastructure and economic growth in the regional context. This article will consider the impact on GRP per capita of the following ICT factors: volume of communication services, number of fixed telephone lines, enterprises using computers, enterprises using the Internet, internal costs for R&D by regions, the number of organizations that have created and use new technologies and equipment. The data for the article were collected over ten years, from 2010 to 2020 as part of the dynamic panel data approach, which includes 14 regions and two cities. The initial data were taken from the statistical data of the Bureau of National Statistics of the Republic of Kazakhstan. The methodology used in the article includes the study of the proposed indicators and conducting correlation and regression analysis in the STATA program. The conclusions presented in our work showed that the ICT infrastructure has a significant positive impact on regional development, and the coefficient of elasticity of the ICT infrastructure to regional development is greater than the coefficient of elasticity of the degree of integration. The government can use the results of this study to develop programs to improve regional development.