G. Király

16319411500

Publications - 3

Isolation of chemical constituents from Filago vulgaris and antiproliferative activity of the plant extract and its flavonoid against human tumor cell lines

G. Király Gy Pinke István Zupkó Zsuzsanna Hajdú Peter Forgo Judit Hohmann

Publication Name: Pakistan Journal of Pharmaceutical Sciences

Publication Date: 2020-07-01

Volume: 33

Issue: 4

Page Range: 1593-1597

Description:

Phytochemical investigation of the whole plant of Filago vulgaris Lam. (Asteraceae) resulted in the isolation and characterization of seven compounds, including a rare methoxylated flavonol (araneol), tetrahydrofurofuranolignans (pinoresinol and syringaresinol), p-hydroxybenzaldehyde, vanillin, vanillic acid and scopoletin. The structures of the compounds were determined by NMR and mass spectroscopy. All compounds were first obtained from this species and reported for the genus Filago. Our results demonstrate that highly methoxylated flavonols lacking substituents on ring B and lignans can be regarded as taxonomic markers for the tribe Inuleae. The lipophilic extract of F. vulgaris was found to have antiproliferative activity against HeLa cells (62.1±0.9% inhibition at 30 µg/ml), and araneol was highly effective against this tumour cell line (IC50 8.36 μM).

Open Access: Yes

DOI: 10.36721/PJPS.2020.33.4.REG.1593-1597.1

Anti-inflammatory activity of melampyrum barbatum and isolation of iridoid and flavonoid compounds

Anita Sztojkov-Ivanov G. Király Edit Wéber Gy Pinke Laura Fási Judit Hohmann Róbert Gáspár Erzsébet Háznagy-Radnai

Publication Name: Natural Product Communications

Publication Date: 2018-03-01

Volume: 13

Issue: 3

Page Range: 235-236

Description:

Melampyrum barbatum Waldst. & Kit. Ex Willd. (Scrophulariaceae) has been used in traditional medicine for the treatment of rheumatic complaints and different skin diseases. In the course of our study the anti-inflammatory activity of the aerial parts of M. Barbatum was evaluated. A MeOH extract was prepared and consecutively partitioned with CHCl3, EtOAc and n-BuOH. The fractions were assayed in in vivo carrageenan-induced rat paw oedema model. The intraperitoneally administered n-BuOH phase exerted marked inhibitory effect (33.6 %, p < 0.01). Multistep chromatographic separation afforded mussaenoside and aucubine from n-BuOH fraction. Moreover, 8-epiloganin, loganic acid and mussaenoside were obtained from EtOAc fraction and apigenin, luteolin, benzoic acid and galactitol from CHCl3 fraction. These data validate the ethnomedicinal use of M. Barbatum for the treatment of inflammatory diseases and reveal that iridoids and flavonoids could be responsible for the anti-inflammatory effect of this species.

Open Access: Yes

DOI: 10.1177/1934578x1801300301

Occurrences of Nanocyperion species in West Hungary - Role of moist plough-lands in conservation

A. Mesterházy G. Király R. Pál A. Király Gy Pinke

Publication Name: Journal of Plant Diseases and Proctection Supplement

Publication Date: 2008-04-28

Volume: Unknown

Issue: 21

Page Range: 413-417

Description:

In the last decades in Hungary biotopes of Nanocyperion species have been reduced significantly according to the melioration and the declining of pasturing. Owing to the habitat loss more species such as the examined Lindernia procumbens, Eleocharis ovata, Centunculus minimus, Limosella aquatica, Juncus sphaerocarpus and Elatine triandra became endangered all over the country. During the researches site requirements of these species were analysed as well as their connection with the cultivated species and the soil cultivation carried out on the plough-lands. According to our experiences in West Hungary actual occurrences of Lindernia procumbens, Centunculus minimus, Juncus sphaerocarpus and Elatine triandra are related strongly to the plough-lands. Eleocharis ovata and Limosella aquatica occur on plough-lands less frequently, exist mainly on other pioneer moist habitats. It can be established in case of all the 6 examined species that their habitat spectrum has extended by the increasing in the territory of ploughs forming spacious convenient biotopes for these species. © Eugen Ulmer KG.

Open Access: Yes

DOI: DOI not available