This study aimed to examine the effects of wearable resistance (WR) training on change of direction ability (CODA), muscle activation patterns, and knee joint stress in athletes. Fifteen healthy male football players participated in a pre- and post-training intervention designed to target the quadriceps, hamstrings, and calf muscles to improve neuromuscular control and joint stability. Surface electromyography (EMG) was used to assess muscle activation, and finite element analysis (FEA) was applied to evaluate stress distribution in the knee joint. Following the WR training program, there was a significant reduction in knee abduction angle during the stance phase (p = 0.001), indicating enhanced joint stability. Strength in the calf muscles increased significantly, while muscle activation levels in the quadriceps (p < 0.001) and hamstrings (p = 0.007) were also elevated. Enhanced co-activation between quadriceps and hamstrings was observed, and FEA demonstrated a significant decrease in the maximal von Mises stress in the anterior cruciate ligament (ACL) and meniscus. These findings suggest that WR training improves CODA and lower limb muscle coordination while reducing internal knee joint stress, potentially lowering the risk of ACL injuries and enhancing athletic performance.