The study examines the spectrum of the thermal and wellness clusters related to water-based health tourism in Hungary. The research is looking for an answer regarding the effects of the organization in clusters from the point of view economic, social and cultural in the thermal baths sector. In this sense, literary research and processing were carried out, and mixed-type professional interviews were conducted. Bearing in mind the unexplored dimensions of thermal clusters in Hungary, the research highlights three areas of action: proactivity, economic incorporation and innovation. The results of these three key defined potentials and the discovery of innovation reserves are the ones that will be addressed primarily in the future. These steps boost health tourism and associated activities. The clusters operating in the field, primarily Pannon Thermal Cluster—PANTERM, have hidden reserves and untapped potentials within the operational frames of the cluster organization. The discovery of the potential in the clusters may drive innovation.