The coronavirus outbreak at the end of 2019 can be cited as a trigger for several drastic consequences. In those years and since, the pandemic brought many changes for which the world was not prepared. The spread and increased prevalence of home-based work is one such consequence. The study of the relationship between working from home and well-being at work is one of the most researched areas in the field of economic psychology today. The main objective of this study was to investigate well-being at work in a Slovak sample and to explore its relationship with working from home. The research methodology was implemented in the form of an online questionnaire at the end of 2023. A total of 772 people participated in the survey. According to the research hypothesis, there is a significant correlation between the form of working from home and a higher average level of well-being at work. The results obtained confirmed the hypothesis that working from home has a positive impact on well-being at work. Furthermore, the results highlight the main risks of work from home in terms of 'home comfort' and 'work-life balance'. In conclusion, the research has shown both the advantages and disadvantages of working from home, and managers should strive to ensure that the well-being of employees is maximized in order to work effectively.