Effects of autonomous trucks' different lateral wander modes have been analyzed in this research using a dload subroutine. Two lateral wander modes, a zero-wander mode in which a truck is programmed to follow a predetermined wheel path without any lateral movement and a uniform wander mode, where the truck uniformly distributes itself along the lateral width of the lane, are used. European class A40 truck has been modeled in ABAQUS code. Results show that fatigue life of pavement increases by 1.45 times if a uniform wander mode is used, which corresponds to a decrease in fatigue life of 14 months if a zero-wander mode is used. In case of rutting progression, 40% acceleration of rutting happens under a zero-wander mode. In case of uniform wander mode, rut depth decreases by 1.25 times against the zero-wander mode.