Introduction: High school education took place in the form of distance learning during SARS-CoV-2 pandemic worldwide, including Hungary. Decreased physical activity and an increase in inactive behaviours may lead to an increased risk of obesity, diabetes, and cardiovascular disease. Objective: Our study focused on changes in physical activity (aerobic exercise, muscle strengthening, team sports) and subjective perceptions of health status in adolescents and young adults during the pandemic. Method: High school students in 66 public schools in 37 cities in Hungary (n = 2508) were surveyed. Questionnaire items on physical activity and subjective perceptions of health were adapted from the WHO Health Behaviour of School-aged Children Survey and the Centers for Disease Control and Prevention Youth Risk Behavior Survey. 2 × 2 × 4 factorial ANCOVA was used to test the effect of gender and/or age and region on changes in subjective perceptions of physical activity and health before and during distance education. Results: The majority of the high school students reported a decrease in physical activity frequency during the dis¬tance learning period, with an average of 2-3 fewer days of physical activity per week regardless of region. Nearly a quarter of them rated their health as worse during distance learning than before. A higher proportion of those who reported a subjective decline in health also reported a decline in physical activity. Conclusion: A decline in physical activity during the period of distance learning is associated with a decline in subjec¬tive perceptions of health, especially among rural adolescent girls.