Qatar FIFA 2022 was the first FIFA Football World Cup to be hosted by an Arab state and was predicted by some to fail. However, it did not only succeed but also showed a new display of destination sustainability upon hosting mega-sport events and linked tourism. Yet, some impacts tend to be long-term and need further analysis. The study aims to understand both positive and negative impacts on destination sustainability resulting from hosting mega-sport events, using bibliometric analysis of published literature during the last forty-seven years, and reflecting on the recent World Cup 2022 tournament in Qatar. A total of 2519 sources containing 665 open-access articles with 10,523 citations were found using the keywords “sport tourism” and “mega-sport”. The study found various literature researching the economic impacts in-depth, less on environmental impacts, and much less on social and cultural impacts on host communities. Debates exist in the literature concerning presumed economic benefits and motivations for hosting, and less on actual results achieved. Although World Cup 2022 is considered the most expensive among previous versions, destination sustainability seems to have benefited from the event’s hosting. Socio-cultural impacts of hosting mega-sport events seem to be addressed to an extent in the Qatar version of the World Cup, as well as environmental impacts while creating a unique image for FIFA 2022 and the destination itself. FIFA showcased this as using carbon-neutral technologies to create the micro-climate including perforated walls in the eight state-of-the-art stadiums, with the incorporation of a circular modular design for energy and water efficiency and zero-waste deconstruction post-event. The global event also drew attention and respect to the local community and underprivileged groups such as people with disabilities. Further research is needed to understand the demand-side perspective including the local community of Qatar and the event’s participants, and to analyze the long-term impacts and lessons learned from the Qatari experience.