The expression of green and sustainable chemistry has gained significant attention around the world in recent years. Nowadays, it is evident that green and sustainable chemistry is necessary for Sustainable Development Goals (SDGs); however, the concept and its realisation seem quite vague. Until 2021, green and sustainable chemistry had been defined in different documents, which led to divergent practices. However, in 2021, the United Nations Environment Programme (UNEP) created a Framework Manual on Green and Sustainable Chemistry, which now serves as a uniform guidance for various stakeholders to realise innovation actions and assess management practices for green and sustainable chemistry. Despite its significance, the Framework Manual is not widely known, as it has hardly been analysed, and more seriously, its legal classification has not been examined so far. The aim of this paper is to fill this gap and analyse the Framework Manual from a regulatory viewpoint. In line with this, the study presents the main characteristics of the document, determines the correct legal classification of the document, and makes recommendations regarding the possible improvements of the document and the future regulating options for green and sustainable chemistry. By analysing these questions, the study arrives at significant results: Firstly, it declares that the Framework Manual is a legally non-binding, soft law document. Secondly, it identifies the advantages and disadvantages of soft law regulation. Thirdly, it concludes that the Framework Manual cannot be regarded as a final result. The topic of green and sustainable chemistry should be regulated in a legally binding form in the future. With these results, the study fills the huge gap in legal analysis of the Framework Manual and contributes to the satisfactory future regulation of green and sustainable chemistry.