This study explores the relationship between abiotic factors, farming practices, and weed growth in winter wheat fields in Eastern Hungary. It examines the order of weed dominance and the influence of soil, environmental, and agricultural variables on weed composition and diversity before herbicide application. The research was conducted across four sub-regions in the Great Hungarian Plain, each with distinct soil, hydrological, and geographical conditions. Between 2018 and 2021, 103 fields were surveyed and weed species cover was recorded using EPPO-based identification and quadrat sampling. Soil properties, environmental conditions, and farming practices were documented through soil analysis, geographical data, and farmer interviews. Statistical analyses were preformed including ANCOVA, redundancy analysis, and Shannon diversity index calculations. The results show that common weed species include Veronica hederifolia, Stellaria media, and Apera spica-venti, with winter annuals dominating. Soil compaction and salinity affected weed diversity, while increased copper and zinc concentrations had minor effects on weed coverage. Farming practices, particularly tillage systems and fertilizer use, had a significant effect on species richness and diversity. Different regional and annual weed distributions were observed, with correlation between certain tillage systems and specific weed species. The results emphasize the need for climate-conscious farming practices, and we recommend prioritising shallow cultivation and deep loosening over ploughing in order to manage weed populations effectively. These insights contribute to sustainable weed management strategies in cereal production.