Dipan Uppal

57203063847

Publications - 1

Global, regional and national burden of ischemic heart disease attributable to suboptimal diet, 1990–2023: a Global Burden of Disease study

Marcin W. Wojewodzic Dinesh Upadhya Ahmed Bilal Waqar Kazumasa Yamagishi Zhiyong Zou Y. Waheed Suowen Xu Abdul Rohim Tualeka Dakshitha Praneeth Wickramasinghe Mircea Tampa Nuwan Darshana Wickramasinghe Rasiah Thayakaran Felicia Wu Rajshree Thapa Pugazhenthan Thangaraju Dehui Yin Isidora S. Vujcic Galal Yahya Mohamad Hani Temsah Yunquan Zhang Shoban Babu Varthya Muhammad Umair Marcos Roberto Tovani-Palone Domenico Trico Casper J. P Zhang Madhur Verma Aurora Zanghì Xiao Dong Zhou Dong Keon Yon Bin Zhu Nguyen Tran Minh Duc Habib Yaribeygi Mohammed Zawiah Jibrin Sammani Usman Tommi Juhani Vasankari Loc Tri Vu Peter Willeit Dominique Vervoort Pengpeng Ye Kavumpurathu Raman Thankappan Dipan Uppal Min Seo Kim Ramna Thakur Anggi Lukman Wicaksana Naohiro Yonemoto Stefanos Tyrovolas Chuanhua Yu Yuichi Yasufuku Zenghong Wu Andrea Werdecker Khaled Trabelsi Mary Njeri Wanjau Jacques Lukenze Tamuzi Shuduo Zhou Nguyen Tran Minh Duc Aniefiok John Udoakang Haosu Tang Sojit Tomo Lakshmi Thangavelu Ghazal Zoghi Masayuki Teramoto Toyiba Hiyaru Wassie Georgios Ioannis Verras Joe Varghese Subah Abderehim Yesuf Nathan Y. Tat Anthony Zhong Zhiqiang Zhang Abzal Zhumagaliuly Thang Huu Tran Manish Vinayak Thien Tan Tri Tai Truyen Asokan Govindaraj Vaithinathan Sa’ed H. Zyoud Magdalena Zielińska Asokan Govindaraj Vaithinathan Krishna Tiwari Jansje Henny Vera Ticoalu Nghia Minh Tran Munkhtuya Tumurkhuu Quynh Thuy Huong Tran Jef Van den Eynde Yanzhong Wang Xiaoyue Xu Mohammed Y. Youssef Wanqing Xie Xingxin Wang Hanqing Zhao Yuichiro Yano Yihun Miskir Wubie Claire Chenwen Zhong Salih M.Mustafa Salih Zebari Sa’ed H. Zyoud Yuichi Yasufuku Lakshmi Thangavelu Tewodros Eshete Wonde Rekha Thapar Xing Wang Casper J. P Zhang Liqun Zhang Mohammed G. M Zeariya Era Upadhyay Ali H. Mokdad Marcello Tonelli Iman M. Talaat Mathilde Touvier

Publication Name: Nature Medicine

Publication Date: 2026-04-01

Volume: 32

Issue: 4

Page Range: 1454-1478

Description:

Ischemic heart disease (IHD) remains a leading cause of death worldwide, with dietary risks being its most significant modifiable factor. Here, using the Global Burden of Diseases, Injuries and Risk Factors Study 2023, we estimated the mortality and disability-adjusted life years from diet-related IHD across 204 countries. In 2023, a suboptimal diet was responsible for 4.06 million (95% uncertainty interval (UI) 0.74–6.22) IHD deaths and 96.84 million (18.82–142.52) IHD disability-adjusted life years. The global age-standardized death rate of IHD attributable to suboptimal diet decreased by 43.92% (95% UI 34.44–53.23) per 100,000 population from 1990 to 2023. Among dietary factors, low intake of nuts and seeds (9.87, 95% UI 2.84–17.12 deaths per 100,000 population), low whole grains (9.22, 4.73–13.67), low fruits (7.25, 1.54–13.34) and high sodium (7.15, 0.92–17.97) were primary contributors to IHD deaths. The burden was particularly pronounced in low- and middle-sociodemographic index countries. By disentangling dietary risk factors, we identified the portion of IHD burden directly modifiable through food interventions.

Open Access: Yes

DOI: 10.1038/s41591-026-04250-8