Pavanchand H. Shetty

60007114400

Publications - 1

Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study

Muhammad Suleman Masood Ali Shaikh Jiseung Kang Sa’ed H. Zyoud Chuanhua Yu Naohiro Yonemoto Manish Vinayak Georgios Ioannis Verras Siavash Vaziri Hyeon Jin Kim Min Seo Kim Magdalena Zielińska Bin Zhu Paul Yip Dehui Yin Renjulal Yesodharan Tommi Juhani Vasankari Joe Varghese Jef Van den Eynde Munkhtuya Tumurkhuu Abdul Rohim Tualeka Evangelia Eirini Tsermpini Alexander C. Tsai Samuel Joseph Tromans Aristidis Tsatsakis Atta Ullah Masayuki Teramoto Mohamad Hani Temsah Reem Temsah Yonas Getaye Tefera Vinay Suresh Vetriselvan Subramaniyan Dan J. Stein Chandrashekhar T. Sreeramareddy Joan B. Soriano Roman Shrestha Sunil Shrestha Pavanchand H. Shetty Premalatha K. ShettyS Minale Tareke Seyed Afshin Shorofi Soroush Soraneh Amin Sharifan Ujjawal Sharma Manoj Sharma Javad Sharifi Rad Alfiya Shamsutdinova Ireneous N. Soyiri Aminu Shittu Sunder Sham Anthony Zhong Jingya Zhang Haijun Zhang Mohammed G.M. Zeariya Aurora Zanghì Marcos Roberto Tovani-Palone Jovana Todorovic Marco Torrado Tenaw Yimer Tiruye Kavumpurathu Raman Thankappan Baljinder Singh Jasvinder A. Singh Luís Manuel Lopes Rodrigues Silva João Pedro Silva Inga Dora Sigfusdottir Emmanuel Edwar Siddig Mahabalesh Shetty Ali Sheidaei Vishal Sharma Angga Wilandika Nuwan Darshana Wickramasinghe Yuan Pang Wang Mandaras Tariku Walde Isidora S. Vujcic Shu Wang Asokan Govindaraj Vaithinathan Saeed Ullah Nguyen Tran Minh Duc Thang Huu Tran Mircea Tampa Seyyed Mohammad Tabatabaei Rafael Tabarés-Seisdedos Lukasz Szarpak Chandan Kumar Swain Payam Tabaee Damavandi Alireza Shakeri Masood Ali Shaikh Aniefiok John Udoakang Matiwos Soboka Mehran Shams-Beyranvand Y. Waheed Farrukh Sobia Anna Aleksandrovna Skryabina Valentin Yurievich Skryabin Surjit Singh Fathiah Zakham Hadiza Yusuf Zwanden Sule Yahaya Harmanjit Singh Sa’ed H. Zyoud Asokan Govindaraj Vaithinathan Paramdeep Singh Shu Wang Ker Kan Tan Pavanchand H. Shetty Premalatha K. ShettyS Marco Torrado

Publication Name: Nature Medicine

Publication Date: 2026-02-01

Volume: 32

Issue: 2

Page Range: 527-544

Description:

Drug use disorders (DUDs) are emerging global public health challenges. Here we investigated the global and regional estimates of the prevalence and burden of DUDs, including amphetamine, cannabis, cocaine and opioid use disorders, from 1990 to 2023 for 204 countries and territories by using the Global Burden of Disease Study 2023. Overall, trends in global age-standardized disability-adjusted life-years of DUDs increased from 169.3 (95% uncertainty interval (95% UI), 134.4–203.9) per 100,000 people in 1990 to 212.0 (95% UI, 179.2–245.6) in 2023. In 2023, both prevalence and burden of DUDs were higher in high-income countries, particularly in the USA. The most prevalent DUDs in 2023 were cannabis use disorder (age-standardized prevalence, 270.8 (95% UI, 201.7–350.0) per 100,000 people) and opioid use disorder (205.9 (95% UI, 178.7–235.0)). Particularly, opioid use disorder showed a nearly twofold increase in prevalence and burden between 1990 and 2023. In 2023, compared with countries where cannabis use was illegal, countries permitting both recreational and medical cannabis use had higher prevalence rates for all types of DUDs. Proactive and effective policies are essential to mitigate the increasing global burden of DUDs.

Open Access: Yes

DOI: 10.1038/s41591-025-04137-0