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Found 6515 publications
Wedelolactone Inhibits Hepatitis B Virus Replication by Modulating NF-κB and Nrf2/HO-1 Signaling: An in-vitro Huh7 1.3-mer HBV Plasmid Model
Publication Name: Iranian Journal of Pharmaceutical Research
Publication Date: 2026-12-01
Volume: 25
Issue: 1
Page Range: Unknown
Description:
Background: Chronic hepatitis B virus (HBV) infection is a well-recognized cause of hepatic injury through prolonged viral replication, inflammation, and oxidative stress. Existing antiviral drugs limit viral replication but cannot eliminate viral transcription or even totally preclude liver injury, thus reemphasizing the significance of drugs with combined antiviral and hepatoprotective effects. Objectives: To evaluate the effects of wedelolactone on HBV replication, gene expression, inflammation, and oxidative stress in an in-vitro model of HBV plasmid transfection with human hepatic cells. Methods: Human hepatocellular carcinoma cells (Huh7) were transfected with a 1.3-mer plasmid and treated with wedelolactone (2.5 - 10 µM). Luciferase assays for HBV promoter activity, Northern blotting and Southern blotting for transcripts and replicative intermediates, qPCR for extracellular HBV DNA, and western blotting for viral antigens such as HBx were performed. Cell cytotoxicity was measured. NF-κB/IκB, inflammatory cytokines (TNF-α, IL-6), and antioxidant markers (Nrf2, HO-1, Keap1) were assessed to evaluate inflammatory and oxidative responses. Results: Wedelolactone significantly suppresses HBV promoter activity, RNAs, core particle formation, and extracellular HBV DNA. It reduced the expression of HBcAg and HBsAg. It inhibited NF-κB activation and cytokine release, while simultaneously enhancing Nrf2/HO-1 signaling, including induction of heme oxygenase-1 by lowering levels of Keap1. Conclusions: Wedelolactone exerts dual antiviral and hepatoprotective actions by inhibiting HBV replication and modulating inflammatory and oxidative stress pathways.
Open Access: Yes
DOI: 10.5812/ijpr-168329
Courier, Express, Parcel market with a complex system interpretation-The Hungarian case
Publication Name: 2024 IEEE 15th International Colloquium of Logistics and Supply Chain Management Logistiqua 2024
Publication Date: 2024-01-01
Volume: Unknown
Issue: Unknown
Page Range: Unknown
Description:
The parcel delivery market functions as a complex system, according to the authors of this article. By comprehending and outlining the unique characteristics of the complex system, the authors aim to substantiate their assertion. The Covid pandemic in Hungary's Courier, Express, and Parcel market in 2020 caused a previously unprecedented increase in parcel delivery demands similarly to other countries. The epidemic-related rise in e-commerce additionally resulted significant changes to the approach by which the parcel delivery industry operated. Unexpected collaboration amongst service providers started to emerge on the parcel market in 2021. These alterations are of a kind that suggests the behavioural characteristics of a complex system. Considering that the leading service providers' autonomous operations constitute the primary characteristic of the Hungarian parcel delivery market, an analysis from a scientific perspective of the events that transpired in the Hungarian parcel delivery market is imperative to understand the reasons for this shift. Two research questions have been formulated by the authors, one of which investigates whether the parcel delivery market is considered as a system (complex system), it is conceivable for collaboration to emerge spontaneously if this is the most effective form for the system. The other research question concerns whether cooperation can be established in a market without external interference. To provide an explanation for the developments that transpired between 2020 and 2022, the authors analyse the Hungarian parcel delivery market as a complex system. In complex systems, transformation and self-organization occur naturally when the system decides that a particular shape is best for it in its current environment. During the time under review, the equilibrium of the parcel delivery market in Hungary was disrupted by the unanticipated rise in e-commerce, and the increased demands of customers nearly brought the service providers to a state of chaos. Consequently, the behaviour of service providers started to shift from their previous standards. The article's uniqueness is in its classification of the parcel delivery market as a complex system, which can be used to anticipate the current and expected behaviour of the stakeholders.
Open Access: Yes
The effect of digital curation on visitor behavior in museum expositions
Publication Name: Journal of Infrastructure Policy and Development
Publication Date: 2024-01-01
Volume: 8
Issue: 9
Page Range: Unknown
Description:
This study examines the impact of digitally curated museum exhibitions on visitor behavior, with a particular focus on university students from China and Hungary (n = 308). Using PLS-SEM analysis, the research finds that visitors’ experiences during digital curation visits significantly influence their behavior, and this influence is mediated by perceived value and satisfaction. It is recommended that museums consider the following constructive considerations to facilitate their future development: expanding the application of digital curation, utilizing cutting-edge technologies, implementing data-driven curatorial optimization, enhancing social experiences, integrating education and entertainment, and promoting cultural preservation and environmental stewardship. These insights will help guide museums toward more engaging and sustainable experiences.
Open Access: Yes
Explaining the variation in sustainable development through the lens of key macroeconomic and environmental factors
Publication Name: Discover Sustainability
Publication Date: 2026-12-01
Volume: 7
Issue: 1
Page Range: Unknown
Description:
This paper investigates the role ofenvironmental and macroeconomic stabilityin achieving sustainable developmentin Pakistan from 1990 to 2022.The objective of this study is to investigate the contagion effects of both ecological and macroeconomic variables on Pakistan's sustainable development, employing the structural VAR methodology. The research addresses an important gap in the literature to jointly analyze macroeconomic stability and environmental sustainability within a unified framework for a developing economy like Pakistan. The need for this study arises from Pakistan’s dual challenges of persistent macroeconomic instability and rising environmental stress, which together threaten progress toward the Sustainable Development Goals (SDGs). Positive energy shocks are strongerth annegative shocks arising from CO2 , external debt, and inflationin explicating variation inPakistan’s sustainable development. The study finds that renewable energy consumption has the most significant long-term impact on sustainable development, accounting for 33.83% of the forecast error variance. Overall, 55.50% of sustainable development is predicted by environmental factors,14.66% by macroeconomic variables, and 29.84% by its shock. Such results lead to accepting the hypothesis that ecological and macroeconomic stability significantly affect the sustainable development of Pakistan. In the long run, renewable energy consumption has a positive impact on sustainable development, promoting energy security, supporting economic growth, and maintaining environmental stability. The results of diagnostic tests suggest that the structural VAR approach is specified correctly. This study recommends that all economic policies be designed to highlight the need for comprehensive reforms that align economic stability with environmental resilience to achieve sustainable development. In the context of Pakistan, positive shocks arising from renewable energy consumption demonstrate a stronger influence on variations in sustainable development compared to negative shocks arising from CO₂ emissions, external debt, and inflation. This highlights the central role of energy transitions in achieving sustainability.
Open Access: Yes
MHD Casson nanofluid flow over a vertical stretchable sheet saturated with a porous medium: a parametric approach for sensitive analysis
Publication Name: Discover Nano
Publication Date: 2026-12-01
Volume: 21
Issue: 1
Page Range: Unknown
Description:
Purpose: After being motivated by the diverse applications of blood rheology, nanotechnology, magnetic field, chemical reaction, solar radiation, and non-Darcy porous media in nano-industrial, medical, and chemical engineering domains. The current computational study aims to numerically examine the influences of velocity slip, internal thermal generation or absorption, chemical reactions, and thermal radiation on magneto-hydrodynamic blood-based nanofluid flow with thermo-Brownian motion through an extending interface within a high-permeability medium. Furthermore, the sensitive analysis of flow features with respect to the independent flow parameters is considered. Design/methodology/approach: Suitable similarity equations are employed to convert the partial differential equations into ordinary differential equations together with their boundary constraints. The NDSolve method in Mathematica 11.0 is employed to numerically analyze the flow model, yielding data for the stream function, velocity profile, frictional force coefficient, temperature profile, concentration profile, local Nusselt number, and Sherwood number across several rheological parameters. Main findings: A boundary slip diminishes momentum transmission from the fluid to the surface; when velocity slip escalates, the velocity profile declines. The intensity of the thermal boundary layer escalates with the thermal Grashof number. The temperature distribution is exacerbated by the influence of radiation. As the Brownian parameter grows, the nanofluid temperature intensifies. The chemical reaction parameter substantially affects the enhancement of both skin friction and the Sherwood number. The Nusselt number is enhanced by increasing the thermal Grashof number. The sensitivity analysis indicates that the chemical reaction and concentration Grashof number significantly influence the improvement of rheological properties. Applications: The results of this work are relevant for regulating film thickness, chemical vapour deposition, drug delivery systems, and process optimization.
Open Access: Yes
A Novel, Three-Stage Intelligent Fuzzy Traffic Signal Control System
Publication Name: Acta Polytechnica Hungarica
Publication Date: 2024-01-01
Volume: 21
Issue: 8
Page Range: 189-209
Description:
Traffic congestion is a serious issue for cities and urban areas, owing to the increasing usage of vehicles. This phenomenon results in several negative consequences, such as high fuel consumption and loss of time. To address this problem, several countries have implemented optimal traffic signal control systems. However, these systems have some drawbacks, such as the need for expensive hardware and maintenance difficulties. Because the sensors are buried under the road surface, the system often cannot account for the full length of the vehicular queue. This, among several issues, inhibits the full potential of the technology’s effectiveness and sustainability. In addition, there is much uncertainty in traffic conditions, which points to the need for a model that includes vagueness in the control system. This study proposes a novel hierarchical structure for a three-stage fuzzy traffic control system. This new system assesses the vehicle queue, identifies heavy traffic, detects emergency cars, and adjusts the duration of traffic lights according to the traffic flow and waiting times of vehicles using fuzzy inference rules. This controller was evaluated and validated using a micro-simulation model of an isolated intersection. The obtained results revealed the increased adaptability and flexibility of the proposed system owing to its potential to differentiate a random number of traffic directions. It is also able to handle emergency vehicles and can decrease waiting times, stalling fewer cars, if there is a high traffic flow in the conflicting direction(s) and is a robust and scalable system with lower computational costs.
Open Access: Yes
Design of lqr controller for gan based buck converter
Publication Name: Pollack Periodica
Publication Date: 2020-08-01
Volume: 15
Issue: 2
Page Range: 37-48
Description:
This paper presents a design procedure of a switched-mode power converter, the well-known synchronous buck converter: The calculating method, and how to choose the parts of the converter are presented in detail, like the inductor, the capacitor and the semiconductors as well as the design of the state feedback. During the design process the efficiency and the high switching frequency are very important: The switching semiconductors are Gallium Nitride based. Then, a linear-quadratic regulator is designed and applied to the particular case of a buck converter.
Open Access: Yes
The Impact of Biodegradable and Compostable Plastic Products on the Occurrence and Contamination of Microplastics in Compost Leachate
Publication Name: Chemical Engineering Transactions
Publication Date: 2024-01-01
Volume: 114
Issue: Unknown
Page Range: 835-840
Description:
The composting of organic and bio-waste is widely practised, and in some regions, it is even a mandatory waste management practice. A valuable by-product of this process is the nutrient-rich liquid known as compost leachate, which holds great potential for use in agriculture and horticulture. This investigation delves into the content, production methods, and impact of compost leachate on different crops while also emphasising its susceptibility to external factors. Compost leachate forms during composting and serves as an effective soil amendment material containing essential nutrients, microorganisms, and humic acids beneficial for plant growth. The quality of this by-product can be compromised by contamination from organic waste materials. Today, there has been widespread adoption of biodegradable or compostable plastic products in household composting systems due to misconceptions or public attitudes towards their usage. In-home composting, the process of decomposition might be slower, and there could be issues with the conventional waste management systems that are still commonly used. Additionally, not all degradable products are exclusively made from natural materials. Sometimes, synthetic polymer chains are utilised to accelerate degradation. This study aims to explore, through a simulated experiment, the possibility of microplastic contamination in composting environments, primarily due to the presence of biodegradable and compostable plastic items in these settings. The research findings indicate that the potential risks of microplastics to compost and compost leachate have been insufficiently explored, only recently becoming a focal point. The key conclusions suggest that the development of strategies to address these ecotoxicological factors is becoming increasingly pressing.
Open Access: Yes
DOI: 10.3303/CET24114140
Integral operators in relation to the HOSVD-based canonical form
Publication Name: Asian Journal of Control
Publication Date: 2015-03-01
Volume: 17
Issue: 2
Page Range: 459-466
Description:
This paper describes the relation of the higher order singular value decomposition (HOSVD) based canonical form to the Hilbert-Schmidt type integral operators. This connection between the canonical form of f(x) and the integral operators determined by function f(x) is important; on the one hand it gives a new aspect for the consideration of LPV models, and on the other hand it allows for the approximation of eigenfunctions and integral operators based on a numerical reconstruction of the canonical form.
Open Access: Yes
DOI: 10.1002/asjc.1017
