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Found 6423 publications

First Successful Treatment Reported with Pembrolizumab in a Patient Diagnosed with Choriocarcinoma in Hungary

Vilmos Fülöp Kornél Lakatos László Kalmár Erzsébet Gyöngyvirág Bíró Erika Lahm

Publication Name: Life

Publication Date: 2026-03-01

Volume: 16

Issue: 3

Page Range: Unknown

Description:

Pembrolizumab is a programmed cell death protein (PD-1) inhibitor, humanized antibody widely used in cancer immunotherapy. Choriocarcinoma is an aggressive type of gestational trophoblastic neoplasia. Its treatment is based on surgical removal of the tumorous tissue and systemic chemotherapy; however, in some chemoresistant cases, immunotherapy can also be a valid option. Here, we report the first successful programmed death inhibitor-based treatment of a patient diagnosed with stage IV, ultra-high-risk choriocarcinoma in Hungary.

Open Access: Yes

DOI: 10.3390/life16030481

Effect of GNSS Spoofing on GNSS-IMU Data Fusion-based Vehicle Pose Estimation

Péter Bauer

Publication Name: IFAC Papersonline

Publication Date: 2025-10-01

Volume: 59

Issue: 30

Page Range: 150-155

Description:

This paper examines the effect of GNSS spoofing on GNSS-IMU fusion-based position, velocity and attitude estimates. First, it proposes and tunes an estimator considering also IMU sensor biases and real flight data of a multicopter. Then it feeds the estimator with IMU data from a fixed flight trajectory and GNSS data from different trajectories with increasing divergence from the fixed one simulating a perfect spoofing scenario. Detailed examination of the estimates shows that spoofing has non negligible effect on velocity and especially attitude estimates. Thus any spoofing detection algorithm can not be based on attitude estimates which utilize GNSS data.

Open Access: Yes

DOI: 10.1016/j.ifacol.2025.12.228

Impact of Autonomous Vehicles on Roundabout Capacity

Csaba Koren Attila Borsos Viktor Nagy Othmane Boualam

Publication Name: Sustainability Switzerland

Publication Date: 2022-02-01

Volume: 14

Issue: 4

Page Range: Unknown

Description:

Studying the impact of AVs on our road infrastructure offers a lot of potential in the transportation domain; one of these issues is how capacity will be affected. This paper presents a contribution to this research area by investigating the impact of AVs on the capacity of single-lane roundabouts using a microsimulation model. For the development of the model, a roundabout situated in Győr (Hungary) was selected and field data on the roundabout geometric characteristics as well as traffic volumes were used. Simulations using Vissim were run for various scenarios based on varying input traffic volumes and market penetration rates of AVs to assess queue lengths. The highway capacity manual (HCM) roundabout model was used to estimate the capacity of the existing roundabout. Values of follow-up times and critical gaps were set to decreasing as the penetration rate of AVs increases. The results demonstrated that 20% and 40% AVs in the flow would increase leg capacities by about 10% and 20%, respectively. Furthermore, a reduction in excessive queue lengths was estimated and capacities and queue lengths were calculated by legs. It was found that these are highly influenced by the distribution of flows among legs, and the share of flows in various directions.

Open Access: Yes

DOI: 10.3390/su14042203

SCHEDULING OF WASTE WOOD PROCESSING FACILITIES WITH OVERLAPPING JOBS

Máté Hegyháti Balazs David Olivér Osz

Publication Name: Proceedings of the 16th International Symposium on Operational Research in Slovenia Sor 2021

Publication Date: 2021-01-01

Volume: Unknown

Issue: Unknown

Page Range: 321-326

Description:

An important phase in most waste wood value chains is the processing of bulk waste from various sources, usually by means of shredding. This paper presents a method for scheduling the machines in such a waste wood processing facility, where incoming deliveries of different types of wood are processed by a series of treatment and transformation steps to produce shredded wood. A mathematical model is presented for the problem, that allows overlaps between consecutive steps to optimize resource flow through the system. The efficiency of the model is presented on randomly generated instances.

Open Access: Yes

DOI: DOI not available

Predatory Medical Journals in Patent Literature: A Hidden Threat

Lóránt Dávid Mehdi Dadkhah Mihály Hegedűs

Publication Name: Advanced Pharmaceutical Bulletin

Publication Date: 2025-11-01

Volume: 15

Issue: 4

Page Range: 693-699

Description:

Purpose: The negative impact of potential predatory journals has been widely discussed, primarily within academic contexts. However, their influence beyond academia remains underexplored. This study aims to address that gap. Methods: The current editorial utilised a sample list of 8 potential predatory medical journals. We compiled a list of potential predatory medical journals using the discontinued titles list in Scopus and the current blocklists. Then their patent-to-paper citations have been examined to understand the dissemination of questionable medical publications outside of academia. Results: This indicates that potential predatory medical journals received 483,848 citations from scholarly works and 4,251 citations from patents. Conclusion: When patents cite papers from predatory journals, flawed information may propagate, or potentially leading to wrongful patent rejections and wasted resources. This serves as a warning for the patent community to take action against potential predatory journals.

Open Access: Yes

DOI: 10.34172/apb.025.46153

Developing sustainable logistic strategies in the context of cognitive biases

Péter Földesi Eszter Sós

Publication Name: Infocommunications Journal

Publication Date: 2024-01-01

Volume: Unknown

Issue: Unknown

Page Range: 110-118

Description:

Cognitive biases often occur even in the decision-making process of highly qualified company managers due to the drive for efficiency and time pressure in operations. At the same time, there are also long-term strategic decisions where time pressure is no longer a factor, and yet cognitive bias appears, which has to be considered properly. In strategic issues, decision- makers tend to see their wishes and desires rather than the objective reality. The proposed system of fuzzy indicators based on technical and objective data supports decision-making between logistics strategies by mitigating cognitive biases, which is extremely important in the logistics field, where the decisions have to be made partly based on subjective, vague, or uncertain parameters.

Open Access: Yes

DOI: 10.36244/ICJ.2024.5.13

The impact of tourism services development on income inequality in Kazakhstan’s regions

Lazat Spankulova Bulat Mukhamediyev Azamat Kerimbayev Csaba Kőmíves Bulat Mukhamediyev Laura Kuanova

Publication Name: Problems and Perspectives in Management

Publication Date: 2026-01-01

Volume: 24

Issue: 1

Page Range: 318-331

Description:

This study investigates the relationship between tourism development and income inequality across regions of the Republic of Kazakhstan, using regional panel data for 2003–2024. The empirical analysis is based on an unbalanced panel of 16 regions, comprising 367 region–year observations. Fixed-effects regression models are employed to examine how two distinct dimensions of tourism development (tourism services per capita and tourist accommodation places per capita) affect income inequality measured by the regional Gini coefficient. The results indicate that the intensity of tourism service provision does not have a statistically significant effect on income inequality, even after controlling for cross-sectional dependence. In contrast, tourism accommodation infrastructure capacity is positively and statistically significantly associated with regional income inequality across all model specifications. Additional results show that income inequality is significantly influenced by poverty incidence, income polarization, healthcare expenditures, and the share of the rural population. The coefficients on the per-capita tourist accommodation variable are positive across all specifications. This indicates that the growth of this indicator contributes to increased income inequality. Moreover, the coefficients for the indicators ShServPop and ShServPop(–1) are significant. However, they cannot be relied upon, as Pesaran’s test rejects the hypothesis of cross-sectional independence for these specifications. This suggests that the growth of tourism infrastructure may exacerbate, rather than reduce, regional income differences due to capital concentration, skill-labor-oriented employment, and price effects. The results highlight the need for complementary policies that promote inclusive tourism development and mitigate inequality-enhancing effects of tourism-related infrastructure investment.

Open Access: Yes

DOI: 10.21511/ppm.24(1).2026.22

MEK1/2 Inhibitor (U0126) and PI3K Inhibitor (LY294002) Suppress Herpes Simplex Virus Type 1 Replication by Targeting MAPK/ERK1/2 and PI3K/AKT Signaling Pathways: Implications for Oral Health and Translational Control of Orolabial HSV-1 Infection

D. U. Ozsahin U. Saeed Ilker Ozsahin Zhanping Ren Z. Z. Piracha Yongwei Tao Dilber Uzun Ozsahin Wei Meng

Publication Name: Iranian Journal of Pharmaceutical Research

Publication Date: 2025-01-01

Volume: 24

Issue: 1

Page Range: Unknown

Description:

Background: Current antivirals for orolabial Herpes simplex virus type 1 (HSV-1) often provide incomplete suppression and limited reactivation control, sustaining recurrent oral lesions and inflammation that compromise oral health. HSV-1 subverts host signaling networks to enhance its replication and trigger inflammation. Among these, the extracellular signal-regulated kinase 1/2 (ERK1/2) and phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) pathways are hijacked to facilitate viral gene expression and cell survival. Objectives: In this study, we employed U0126 [a mitogen-activated protein kinase 1/2 (MEK1/2) inhibitor] and LY294002 [a phosphatidylinositol 3-kinase (PI3K) inhibitor] as targeted pharmacological tools to intercept HSV-1’s exploitation of host keratinocyte signaling. Methods: Human HaCaT keratinocytes were infected with HSV-1 and treated with U0126 or LY294002. Western blotting was used to assess phosphorylation of ERK1/2 and activation of protein kinase B (AKT). MTT assays were performed to evaluate cell viability. Real-time PCR was utilized to quantify viral transcripts (ICP0, ICP4, gB, and gC) and inflammatory cytokines [interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α)]. Confocal microscopy was employed to visualize the intracellular distribution of phosphorylated extracellular signal-regulated kinase 1/2 (p-ERK1/2), phosphorylated activation of protein kinase B (p-AKT), and HSV-1 glycoprotein D (gD). Viral titers were determined using plaque assays. Results: The HSV-1 infection induced a time-dependent increase in phosphorylation of ERK1/2 and AKT, with p-ERK1/2 peaking at 12 h and p-AKT increasing 2.5-fold by 24 h. Cell viability declined from 100% at baseline to 45% at 24-hours post-infection (hpi). Treatment with U0126 and LY294002 reduced p-ERK1/2 and p-AKT levels to 25% and 30% of infected controls, respectively, restoring viability to 82 - 86%. Both inhibitors markedly suppressed viral gene expression (ICP0, ICP4, gB, gC down by 60 - 80%) and inflammatory cytokines (IL-6 and TNF-α reduced by > 50%). Plaque assays showed a strong decline in infectious titers — from 175 plaques per well in untreated infection to 60 and 45 plaques after U0126 and LY294002, respectively. Confocal imaging further revealed diminished nuclear accumulation of p-ERK1/2 and p-AKT, indicating disruption of post-entry signaling critical for viral replication. Conclusions: Targeting host signaling bottlenecks with U0126 and LY294002 offers a dual-pronged antiviral strategy against HSV-1 by dismantling the ERK/AKT axis critical for replication and inflammatory amplification. These findings position MEK1/2 and PI3K as promising therapeutic nodes for managing cutaneous HSV-1 infections. This host-directed dual-pathway inhibition may therefore help reduce recurrent orolabial HSV-1 lesions.

Open Access: Yes

DOI: 10.5812/ijpr-164639

Contribution to the knowledge of Rotundabaloghia mites: new species and new records (Acari: Mesostigmata: Rotundabaloghiidae) from the Oriental and Australasian regions

Sergey G. Ermilov Jenő Kontschán

Publication Name: Systematic and Applied Acarology

Publication Date: 2023-03-01

Volume: 28

Issue: 3

Page Range: 405-410

Description:

No description provided

Open Access: Yes

DOI: 10.11158/saa.28.3.1