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Found 6525 publications

Complex oncologic therapy for loco-regionally advanced breast cancer associated with long-lasting SARS-CoV-2 PCR-positivity

István Sipőcz Tamás Kullmann Márta Knausz Dániel Kollár András Drozgyik F. Tamás Molnár

Publication Name: Orvosi Hetilap

Publication Date: 2021-04-01

Volume: 162

Issue: 16

Page Range: 611-614

Description:

Mortality of COVID-19 is increased when certain co-morbidities, among others advanced malignancies are present. Deleterious effect of cytotoxic therapy, related to its immunosuppressive effect, may also be hypothesised. However, postponing or cancelling oncologic treatment, especially in younger patients with advanced and more aggressive tumors may worsen the prognosis. The case of a 39-year-old female patient is presented, who was diagnosed with loco-regionally advanced breast cancer during the pandemic. Primary systemic chemotherapy was started. The patient presented with acute respiratory tract symptoms during the fifth cycle and subsequently SARS-CoV-2 infection was diagnosed. Chemotherapy was cancelled. Symptoms resolved in three days after diagnosis. SARS-CoV-2 PCR remained positive up to day 43. Antihormonal therapy was introduced on day 19 and she underwent mastectomy with axillary lymph node dissection on day 51. Chemotherapy was reset postoperatively on day 82 with prophylactic G-CSF protection. No adverse event was observed throughout the treatment. Cytotoxic chemotherapy and surgery can be successfully delivered in breast cancer patients with prolonged asymptomatic SARS-CoV-2 PCR positivity, even without negative swab result. Individual optimisation of the therapy may require deviations from standard protocols. Closer multidisciplinary cooperation may contribute to the minimisation of both oncologic and infectious risks.

Open Access: Yes

DOI: 10.1556/650.2021.32192

ELASTO-PLASTIC TOPOLOGY OPTIMIZATION UNDER CYCLIC LOADING FOR EFFICIENT STRUCTURAL DESIGN

Gábor Csaba Soóki-Tóth Majid Movahedi Rad Muayad Habashneh Somfai Attila Majid Movahedi Rad

Publication Name: Compdyn Proceedings

Publication Date: 2025-01-01

Volume: Unknown

Issue: Unknown

Page Range: 3401-3412

Description:

This study introduces an elasto-plastic topology optimization approach tailored for structural systems subjected to cyclic loading. By incorporating material nonlinearity, the method provides a robust framework for designing structures that withstand repetitive loading efficiently, avoiding excessive material use. This optimization approach integrates the effects of cyclic loading to enhance structural resilience while minimizing mean compliance. The proposed method is particularly applicable for optimizing structural components in steel frameworks where material efficiency and load-bearing capacity are critical. By emphasizing the elasto-plastic behavior of materials, this study aims to offer a practical tool for engineers seeking resilient structural designs that balance strength and sustainability. Potential applications extend to structural elements in earthquake-resistant buildings, where managing material use is essential for both environmental and economic impact.

Open Access: Yes

DOI: 10.7712/120125.12661.25046

An extended stress-based forming limit diagram focusing on the wrinkling phenomenon and the effect of the normal pressure on clamped surfaces

Zoltán Weltsch Zsolt Lukács Gábor J. Béres Richárd Borbély Martin L. Kölüs Miklos Tisza

Publication Name: Journal of Materials Processing Technology

Publication Date: 2023-12-01

Volume: 322

Issue: Unknown

Page Range: Unknown

Description:

A novel wrinkling limit representation following the pattern of the conventional forming limit curves (FLCs) and the stress-based forming limit curves (SFLCs) as well as the application of the assumed criterion in finite element modelling are discussed in this manuscript. FLCs can partially refer to the wrinkling potential in the area left to the uniaxial tension line, but just like the SFLCs, cannot characterize the limits of the material behavior in a deeper sense, if negative in-plane stress and normal pressure act together on the sheet. This study predicts the wrinkling risk of clamped surfaces with a stress-based criterion through solving the analytical equations of the critical compressive stress causing wrinkling, and the corresponding blank holder pressure. The critical values were calculated based on the Wang and Cao's theory using Hill48 anisotropic yield function coupled with the Swift hardening law. The results draw a novel wrinkling limit curve representation methodology, in which the minor stress responsible for wrinkling and its ratio to the major stress are distinguished in the function of the applied blank holder pressure. The applicability of the calculated curves was investigated using finite element simulations, which showed that this method provides the opportunity to quantitatively interpret how close a component is to the wrinkling limit. The calculated wrinkling tendencies were verified by standard cup drawing tests supplemented by round shape error measurements on three different automotive steel sheets. It can be stated that the obtained numerical conditions of wrinkling were fitted to the experiments fairly well.

Open Access: Yes

DOI: 10.1016/j.jmatprotec.2023.118196

IP Packet Forwarding Performance Comparison of the FD.io VPP and the Linux Kernel

Melinda Kosák G. Lencse

Publication Name: Infocommunications Journal

Publication Date: 2025-01-01

Volume: 17

Issue: 2

Page Range: 35-44

Description:

There are numerous free software solutions for IPv4 or IPv6 packet forwarding. The Fast Data Project / Vector Packet Processing (FD.io VPP) is a novel and prominent solution. This paper investigates its performance and scalability compared to that of the Linux kernel. The investigation was conducted in accordance with the requirements outlined in the relevant Request for Comments (RFC) documents (RFC 2544, RFC 4814, and RFC 5180) using the siitperf measurement software. Two different test environments were used to eliminate the potential hardware-specific side effects and to gain insight into the performance and scalability of the IPv4 and IPv6 packet forwarding capability of the two investigated solutions. It was found that FD.io VPP outperformed the Linux kernel by approximately an order of magnitude. The configuration of FD.io VPP, along with the details of the measurements, are provided, and the results are presented and analyzed in the paper.

Open Access: Yes

DOI: 10.36244/ICJ.2025.2.5

'Lovers of Beauty': The oeuvres of george santayana, fred holland day and edward perry warren as exemplifications of aesthetics of existence influenced by the platonic eros

Nóra Horváth

Publication Name: Brno Studies in English

Publication Date: 2015-01-01

Volume: 41

Issue: 2

Page Range: 5-21

Description:

My theory is about the lovers of beauty who tried to aestheticize their existences in different ways, but with the same goal: To make life into an oeuvre. George Santayana created an aesthetic ontology, Fred Holland Day made a photo composition (Beauty is Truth), which is the essence of his aesthetics of existence, and Edward Perry Warren spiritualized the Male ideal shaped through the praising of the Uranian Eros. They used the Hellenic idea as a life-giving energy, they re-eroticised the philosophical thoughts about self-creation and the aesthetic way of life. The serious questions of private perfection and self-creation can be the basis of an ethics of personality. According to Agnes Heller it is always the ethics of one person. We have to illustrate it, if we want to speak about it. So, we have to examine one paradigmatic case to illustrate the essence of it.

Open Access: Yes

DOI: 10.5817/BSE2015-2-1

Measurement and simulation of vector hysteresis characteristics

Miklós Kuczmann

Publication Name: IEEE Transactions on Magnetics

Publication Date: 2009-01-01

Volume: 45

Issue: 11

Page Range: 5188-5191

Description:

This paper presents a Preisach model of ferromagnetic hysteresis to simulate the vector hysteresis properties of ferromagnetic materials. Vector behavior has been studied using a single sheet tester with a round shaped specimen at low frequency, and the magnetic flux density vector has been controlled by a digital measurement system. Circular magnetic flux density pattern has been measured. An inverse vector Preisach hysteresis model has been developed and identified by applying the measured data. Finally, the inverse model has been inserted into a finite element procedure through the fixed point technique and the reduced magnetic scalar potential formulation. The applicability of the measurement system as well as the developed model has been proven by comparing measured and simulated results. © 2009 IEEE.

Open Access: Yes

DOI: 10.1109/TMAG.2009.2031072

The Environmental and Global Impact of Pharmacogenomics: Advancing Green Pharmacy Toward Sustainable and Inclusive Precision Medicine

Pálma Porrogi Pálma Porrogi

Publication Name: Journal of Personalized Medicine

Publication Date: 2026-04-01

Volume: 16

Issue: 4

Page Range: Unknown

Description:

Traditional one size fits all pharmacotherapy often yields suboptimal clinical outcomes, preventable adverse drug reactions (ADRs), and significant drug waste, imposing substantial economic and ecological burdens on healthcare systems. This review evaluates the transformative potential of pharmacogenomics (PGx) testing, particularly cytochrome P450 (CYP) gene variants, as a foundation for an ecosystem-centric accountability framework for green pharmacy and links human metabolic variability to specific environmental outcomes. Personalized CYP profiling is shown to minimize the environmental release of unused drugs and potentially ecotoxic metabolites into aquatic ecosystems, in contrast to standard uniform drug use approaches. The limitations of ethnicity-based dosing models, which rely on population genetic variation, are examined in the context of increasing global genetic admixture. It is argued that individual genetic profiling, conceptualized as a PGx-Green Passport, provides a reliable safety standard that accounts for individual differences, thereby enhancing efficiency and well-being in a globalized society. By integrating clinical data, including real-world evidence on hospital utilization, with sustainability frameworks, this review demonstrates that PGx-guided therapy is not only a tool for clinical efficiency but also a fundamental requirement for systematically achieving environmentally sustainable healthcare.

Open Access: Yes

DOI: 10.3390/jpm16040183

Teamwork in higher education: Teamwork as chance of success

Andrea Bencsik I. Marosi

Publication Name: International Journal of Learning

Publication Date: 2009-01-01

Volume: 16

Issue: 5

Page Range: 167-174

Description:

Education, economy and labour market bear important relationships. The ever faster changes and more important preservation of competitiveness force higher educational institutions and economic players to cooperate more effectively. According to their educational, scientific, knowledge-maker and generative characteristics, universities and colleges receive and play a more active role in the development of the economy. Besides the expansion and multitude of higher education these also contribute to the changes in higher educational roles. In this study, which was conducted among higher educational lecturers, first of all we were looking for the answer whether there is a turn to receive practical experience during daily educational system or in the operation of institutions. Continuing this, in our target groups we intended to find out whether there is change in relationships among lecturers themselves, lecturers and their students, lecturers and economic players. We also wanted to find out if there is any possibilities to work in a team and whether we can find any sign of expectations defined by lecturers and employers of the labour market. Is there any improvement in the way of preparation for living up requirements, such as project-work, language - and entrepreneur abilities? What kind of attitude can be recognized in the theoretical, practical and educational methods? © Common Ground, Ildiko Marosi, Andrea Bencsik, All Rights Reserved, Permissions.

Open Access: Yes

DOI: 10.18848/1447-9494/CGP/v16i05/46260

A Novel Approach to the Operationalization of Corporate Local Embeddedness: Cultural Perspectives on Narrativesas Indicators

Zsuzsanna Pálffy

Publication Name: European Journal of Interdisciplinary Studies

Publication Date: 2025-01-01

Volume: 17

Issue: 1

Page Range: 101-123

Description:

Corporate embeddedness, the extent to which companies anchor themselves in a local context through political, economic, academic, social, andenvironmental connections, remains a key area of research in social and regional sciences. Due to the limited availability of secondary data on corporate relationships, measurement methods often rely on qualitative data. Corporate communication, especially CEO letters in annual reports, is a frequently neglected secondary data source that has grown in significance in meeting stakeholder expectations and providing insights into corporate strategies and operations. Despite the growing scholarly interest in CEO letters, little is known about embeddedness narratives and the cultural factors that influence them. Through an analysis of the cultural variations in embeddedness narratives found in CEO letters from the fashion and cosmetics industries, this study suggests a novel approach to operationalising corporate localembeddedness. The focus on these sectors is justified by the significant variations in embeddedness orientations across industries and the accessibility of relevant data. The study finds that CEO letters can serve as a complementary data source for assessing corporate embeddedness, as they reveal both local and global orientations. Using software-based content analysis, key themes and keywords were identified along the Quintuple Helix model, providing a structured approach to analysing embeddedness. The results highlight cultural influences, with reactive cultures emphasising social sustainability, while academic engagement challenges existing assumptions. In addition to reflecting corporate strategies, CEO letters offer insights into sectoral characteristics. However, more qualitative research is still required to fully comprehend a company’s level of embedding.

Open Access: Yes

DOI: 10.24818/ejis.2025.07