Razieh Bahreini

58221294800

Publications - 2

Global, regional, and national burden of headache disorders, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023

Sharareh Eskandarieh Andre Faro Giuseppina Affinito Yaser Mohammed Al-Worafi Abhishek Anil Mohammad Amin Aalipour Hiba Jawdat Barqawi Dariush Abtahi Danish Ahmad Jalal Arabloo Syed Shujait Ali Karem H. Alzoubi Yasser Bustanji Salahdein Aburuz Khursheed Aurangzeb Qorinah Estiningtyas Sakilah Adnani Deldar Morad Abdulah Qorinah Estiningtyas Sakilah Adnani Richard Gyan Aboagye Mohammad Mahdi Bastan Sonu Bhaskar Mohammad Al-Wardat Ganiyu Adeniyi Amusa Demelash Areda Mahsa Asadi Anar Sait Ashina Joseph Uy Almazan Negar Sadat Ahmadi Mohammad Ahmmad Mahmoud Al Zoubi Mohammed Usman Ali Andreas Kattem Husøy Yvonne Yiru Xu Jaimie D. Steinmetz Samir Abu Rumeileh Obed Adonteng-Kissi Ali Ahmed Sawsan Alabbad Yazan Al-Ajlouni Ashraf Alhumaidi Gelana Fekadu Hasan Aalruz Shahzaib Ahmed Jasvinder Singh Bhatti Luis Alberto Cámera C. J. Sanjay Natalia Cruz-Martins Edoardo Caronna Ana Paula Carvalho-E-Silva Jeetendra Bhandari Patrick R. Ching Hongyuan Chu Josielli Comachio Bijit Biswas Arian Azadnia Aleksandr Y. Aravkin Youngoh Bae Sandip Chakraborty Rehana Basri Jina Behjati Mohammad Asghari-Jafarabadi Daniela Contreras Omid Dadras Gurjit Kaur Bhatti Rajbir Bhatti Emanuele D'Amico Anh Kim Dang Lucio D'Anna Bruno Bizzozero-Peroni Archith Boloor Meriem Boukhiam Sindhura Deekonda Pouria Delbari Andreas K. Demetriades Emina Dervišević Lamiaa Labieb Mahmoud Ebraheim Ebrahim Eini Michael Ekholuenetale Vijay Kumar Chattu Razieh Bahreini Maryam Bemanalizadeh Anis Ahmad Chaudhary Xiaochen Dai Vinoth Gnana Chellaiyan Devanbu Amol S. Dhane Bibha Dhungel Joseph Uy Almazan Sohrab Amiri Montaha Al-Iede David B. Anderson Mohammed Albashtawy Fadwa Naji Alhalaiqa Asma Ahmed Ahmed Y. Azzam Soham Bandyopadhyay C. J. Sanjay Natalia Cruz-Martins Valery L. Feigin Azadeh Bashiri Najim Z. Alshahrani Awais Altaf Xueting Ding Huyen Phuc Do Ojas Prakashbhai Doshi Siddhartha Dutta

Publication Name: Lancet Neurology

Publication Date: 2025-12-01

Volume: 24

Issue: 12

Page Range: 1005-1015

Description:

Background: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023 estimates health loss from migraine, tension-type headache, and medication-overuse headache. This study presents updated results on headache-attributed burden from 1990 to 2023, along with clinical and public health implications. Methods: Data on the prevalence, incidence, or remission of migraine, tension-type headache, and medication-overuse headache were extracted from published population-based studies. We used hierarchical Bayesian meta-regression modelling to estimate global, regional, and country-level prevalence of headache disorders. For the first time in GBD 2023, age-specific and sex-specific estimates of time in symptomatic state were applied by meta-analysing individual participant data from 41 653 individuals from the general populations of 18 countries from all parts of the world. Disability weights were applied to calculate years lived with disability (YLDs). Since medication-overuse headache is a sequela of a mistreated primary headache (due to medication overuse), its burden was reattributed to migraine or tension-type headache, informed by a meta-analysis of three longitudinal studies. Findings: In 2023, 2·9 billion individuals (95% uncertainty interval 2·6–3·1) were affected by headache disorders, with a global age-standardised prevalence of 34·6% (31·6–37·5) and a YLD rate of 541·9 (373·4–739·9) per 100 000 population, with 487·5 (323·0–678·8) per 100 000 population attributed to migraine. The prevalence rates of these headache disorders have remained stable over the past three decades. YLD rates due to headache disorders were more than twice as high in females (739·9 [511·2–1011·5] per 100 000) as in males (346·1 [240·4–481·8] per 100 000). Medication-overuse headache contributed 58·9% of the YLD estimates for tension-type headache in males and 56·1% in females, as well as 22·6% of the YLD estimates for migraines in males and 14·1% in females. Interpretation: Headache disorders, in particular migraine, continue to be a major global health challenge, emphasising the need for effective management and prevention strategies. Much headache-attributed burden could be averted or eliminated by avoiding overuse of medication (including over-the-counter medication), underscoring the importance of public education. Funding: Gates Foundation.

Open Access: Yes

DOI: 10.1016/S1474-4422(25)00402-8

Global burden of cancer in children and adolescents aged 0–19 years, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023

Jasvinder Singh Bhatti Sayeh Ezzikouri Ali Hasanpour- Dehkordi Takeshi Fukumoto Seyyed Shamsadin Athari Hala Rashad Elhabashy Aleksandr Y. Aravkin Paul Narh Doku Dariush Haghmorad Theophilus I. Emeto Adeniyi Francis Fagbamigbe Nermin Ghith Anis Ahmad Chaudhary Mahwish Arooj Hamidreza Hasani Robert Kaba Alhassan Salahdein Aburuz Lucas Guimarães Abreu Saeid Anvari Muhammad Sohail Afzal Jonathan M. Kocarnik Mosab Arafat Morenike Oluwatoyin Folayan Hanadi Al Hamad Ayesha Fahim Mohammad Farahmand Lisa M. Force Adewale Oluwaseun Fadaka Nadia M. Hamdy Demelash Areda Veer Bala Gupta Maha Moh'd Wahbi Atout Natalie Pritchett Souad Bouaoud Ayman Ahmed Aso Mohammad Darwesh Cem Bilgin Dong Woo Choi Wafa A. Aldhaleei Awais Altaf Ferrán Catalá-López Danish Ahmad Bashir Dabo Rakhi Dandona Mohammed Albashtawy Mohamed Abouzid Omotayo Francis Fagbule Shirin Barati Soham Bandyopadhyay Ahmed Y. Azzam Abdulfatai Aremu Teferi Gebru Gebremeskel Arvin Haj-Mirzaian Catherine Bisignano Aragaw Tesfaw Desale Benedetta Armocida Hasan Aalruz Kayleigh Bhangdia Isaac Sunday Chukwu Md Kamrul Hasan Promit Ananyo Chakraborty Louise Penberthy Maryam Bemanalizadeh Robert Kokou Dowou Giulia Carreras Xiaochen Dai Maysaa El Sayed Zaki Johannes Haubold Mohammad Asghari-Jafarabadi Fatemeh Afrashteh John Dube Ali Hasanpour- Dehkordi Shahkaar Aziz Logan M. Glasstetter Genanew K. Getahun Sri Harsha Boppana Alistair Acheson Chiranjib Chakraborty Saroja Devi Geetha Razieh Bahreini Yohannes Habtegiorgis Abate Sabah Al-Marwani Mohammad Mahdi Bastan Samuel Demissie Darcho Thao Huynh Phuong Do Miglas Welay Gebregergis Lee Deitesfeld Abdel Rahman E'mar Mohammed Elshaer Lemessa Assefa A. Ayana Chadi Eltaha Awoke Derbie Habteyohannes Abid Ali Safwat Aly Nguyen Hoang Anh Andrew Crist Miranda L. May Maha Moh d.Wahbi Atout Hasan Aalruz Syed Anees Ahmed Demelash Areda Lalit Dandona Karem H. Alzoubi Yasser Bustanji

Publication Name: Lancet

Publication Date: 2026-04-04

Volume: 407

Issue: 10536

Page Range: 1360-1373

Description:

Background Information on childhood cancer burden is crucial for effective cancer policy planning. Unfortunately, observed paediatric cancer data are not available in every country, and previous global burden estimates have not discretely reported several common cancers of childhood. We aimed to inform efforts to address childhood cancer burden globally by analysing results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023, which now include nine additional cancer causes compared with previous GBD analyses. Methods GBD 2023 data sources for cancer estimation included population-based cancer registries, vital registration systems, and verbal autopsies. For childhood cancers (defined as those occurring at ages 0–19 years), mortality was estimated using cancer-specific ensemble models and incidence was estimated using mortality estimates and modelled mortality-to-incidence ratios (MIRs). Years of life lost (YLLs) were estimated by multiplying age-specific cancer deaths by the standard life expectancy at the age of death. Prevalence was estimated using survival estimates modelled from MIRs and multiplied by sequelae-specific disability weights to estimate years lived with disability (YLDs). Disability-adjusted life-years (DALYs) were estimated as the sum of YLLs and YLDs. Estimates are presented globally and by geographical and resource groupings, and all estimates are presented with 95% uncertainty intervals (UIs). Findings Globally, in 2023, there were an estimated 377 000 incident childhood cancer cases (95% UI 288 000–489 000), 144 000 deaths (131 000–162 000), and 11·7 million (10·7–13·2) DALYs due to childhood cancer. Deaths due to childhood cancer decreased by 27·0% (15·5–36·1) globally, from 197 000 (173 000–218 000) in 1990, but increased in the WHO African region by 55·6% (25·5–92·4), from 31 500 (24 900–38 500) to 49 000 (42 600–58 200) between 1990 and 2023. In 2023, age-standardised YLLs due to childhood cancer were inversely correlated with country-level Socio-demographic Index. Childhood cancer was the eighth-leading cause of childhood deaths and the ninth-leading cause of DALYs among all cancers in 2023. The percentage of DALYs due to uncategorised childhood cancers was reduced from 26·5% (26·5–26·5) in GBD 2017 to 10·5% (8·1–13·1) with the addition of the nine new cancer causes. Target cancers for the WHO Global Initiative for Childhood Cancer (GICC) comprised 47·3% (42·2–52·0) of global childhood cancer deaths in 2023. Interpretation Global childhood cancer burden remains a substantial contributor to global childhood disease and cancer burden and is disproportionately weighted towards resource-limited settings. The estimation of additional cancer types relevant in childhood provides a step towards alignment with WHO GICC targets. Efforts to decrease global childhood cancer burden should focus on addressing the inequities in burden worldwide and support comprehensive improvements along the childhood cancer diagnosis and care continuum. Funding St Jude Children's Research Hospital, Gates Foundation, and St Baldrick's Foundation.

Open Access: Yes

DOI: 10.1016/S0140-6736(26)00200-X