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Found 6374 publications

Experiments with the Discrete Bacterial Memetic Evolutionary Algorithm for Solving the Cumulative Capacitated Vehicle Routing Problem

Peter Foldesi Boldizsar Tuu-Szabo Ĺaszĺo T. Ḱoczy

Publication Name: Studies in Computational Intelligence

Publication Date: 2023-01-01

Volume: 1040

Issue: Unknown

Page Range: 87-92

Description:

In this paper we present our initial experiments with the Discrete Bacterial Memetic Evolutionary Algorithm for solving the Cumulative Capacitated Vehicle Routing Problem. The algorithm was tested on instances proposed in the literature. However our method was able to find the optimal solution for small (around 50 nodes) instances, but its convergence speed is low. In the last section some of our ideas to improve the performance of the algorithm were presented.

Open Access: Yes

DOI: 10.1007/978-3-031-07707-4_11

Exploring the hub gene CERS6 as a therapeutic target in type 1 diabetes through a bioinformatics and network analyst approach

Salman Alrokayan Khalid Muhammad D. U. Ozsahin Y. Waheed Muhammad Suleman Hassan Ayaz Tajamul Hussain Muhammad Suleman Asia Nawaz D. U. Ozsahin

Publication Name: Scientific Reports

Publication Date: 2026-12-01

Volume: 16

Issue: 1

Page Range: Unknown

Description:

Insulin-producing β-cells are destroyed in type 1 diabetes mellitus (T1DM), a chronic autoimmune disease that results in complete insulin insufficiency and metabolic dysfunction. According to a survival study that used p values, some hub genes are important for predicting and diagnosing illness. Scientists have inferred medicines to identify possible therapies that interact with the identified hub genes. The GSE10586 gene expression dataset from the Gene Expression Omnibus (GEO) was used for this investigation, which included 27 samples from 15 healthy controls and 12 diabetic patients. Normalization methods such as variance stabilization normalization (VSN) were used as part of the data pretreatment. A protein‒protein interaction (PPI) network was constructed, principal component analysis (PCA) was performed, heatmaps were created, and the Limma algorithm was used to analyze differential gene expression. Using DAVID v6.8 and KEGG pathway annotations, the functional enrichment of differentially expressed genes (DEGs) was evaluated. Furthermore, a computational study revealed CERS6 to be one of the potential hub genes. Four drugs, methotrexate, eliglustat, myriocin and statin, were the focus of further studies on the basis of predictions made via ChemSpider and PubChem database analysis. To determine the optimal binding positions of these drugs with CERS6, we used molecular docking techniques. The binding affinity of methotrexate was 8.48 kcal/mol, that of myriocin was 7.85 kcal/mol, that of eliglustat was − 6.62 kcal/mol, and that of serine was − 4.90 kcal/mol against the binding pocket’s active residues. To determine how consistently each drug interacted with the CERS6 protein over time, molecular dynamics (MD) simulations were run. Throughout the simulation intervals, both medications were confirmed to be stable, with minor alterations in the CERS6 protein loop region. Therefore, the investigation of structure-based drug design has potential for identifying specific therapeutic targets. Ten hub genes were identified via network analysis of differentially expressed genes. These hub genes could serve as novel targets for T1DM detection, prognosis, and targeting. CERS6 exhibited the highest degree of interaction. Methotrexate, eliglustat, myriocin and statins were identified as potential drugs for CERS6. Overall, these findings provide valuable insights that could pave the way for new experimental strategies in T1DM therapy.

Open Access: Yes

DOI: 10.1038/s41598-025-30045-x

Constrained ordered weighted averaging aggregation with multiple comonotone constraints

Lucian Coroianu Marek Gagolewski Robert Fuller Simon James

Publication Name: Fuzzy Sets and Systems

Publication Date: 2020-09-15

Volume: 395

Issue: Unknown

Page Range: 21-39

Description:

The constrained ordered weighted averaging (OWA) aggregation problem arises when we aim to maximize or minimize a convex combination of order statistics under linear inequality constraints that act on the variables with respect to their original sources. The standalone approach to optimizing the OWA under constraints is to consider all permutations of the inputs, which becomes quickly infeasible when there are more than a few variables, however in certain cases we can take advantage of the relationships amongst the constraints and the corresponding solution structures. For example, we can consider a land-use allocation satisfaction problem with an auxiliary aim of balancing land-types, whereby the response curves for each species are non-decreasing with respect to the land-types. This results in comonotone constraints, which allow us to drastically reduce the complexity of the problem. In this paper, we show that if we have an arbitrary number of constraints that are comonotone (i.e., they share the same ordering permutation of the coefficients), then the optimal solution occurs for decreasing components of the solution. After investigating the form of the solution in some special cases and providing theoretical results that shed light on the form of the solution, we detail practical approaches to solving and give real-world examples.

Open Access: Yes

DOI: 10.1016/j.fss.2019.09.006

Comparison of different geometry trees in fire simulation

László Környei Csaba Hajdu F. Hajdu Rajmund Kuti Dóra Beke

Publication Name: Pollack Periodica

Publication Date: 2024-10-16

Volume: 19

Issue: 3

Page Range: 34-39

Description:

Wildfire simulations can help to better understand the dynamics and effects of forest fires. The basis of wildfire simulation is the tree-burning simulation. In this paper, the fire simulation of 7 different geometry Hungarian trees in the case of arson is presented. It was observed that the trees were burned down fast. The maximum mass loss rate and maximum heat release rate were larger as the tree was larger. The largest intensity fire could be observed in the case of the smallest tree. The maximum temperature was higher in the case of a large crown diameter. The maximum aerosol reached high pollutant concentrations. In the case of large crown height, the maximum CO2 concentration was higher. The results presented in this paper can be the basis of the following forest fire simulations.

Open Access: Yes

DOI: 10.1556/606.2024.01022

Bifurcations of the limit directions in extended Filippov systems

Mate Antali

Publication Name: Physica D Nonlinear Phenomena

Publication Date: 2023-03-01

Volume: 445

Issue: Unknown

Page Range: Unknown

Description:

This paper explores special bifurcations that appear in dynamical systems possessing codimension-2 discontinuity sets in the state space. In these systems, the vector field has continuously many directional limits at the discontinuity set. It is shown that the trajectories can reach the discontinuity set along specific limit directions. The number and type of these organising objects characterise the behaviour of the dynamics in the vicinity of the discontinuity set. Thus, bifurcations of limit directions have a remarkable effect on the system. In the paper, two special bifurcations are explored; the tangency bifurcation and the saddle–node bifurcation of limit direction are followed through different formulations of the dynamical system. It is demonstrated that these bifurcations appear in rigid body dynamics in the presence of dry friction.

Open Access: Yes

DOI: 10.1016/j.physd.2022.133622

EXPLORING THE RELATIONSHIP BETWEEN SERVICE PREFERENCES AND DIGITAL INFORMATION SOURCES IN THE CONTEXT OF ACTIVE TOURISM

Lóránt Dávid Gyula Fodor Zsolt Hollósy Ivett Vargáné Gálicz

Publication Name: Geojournal of Tourism and Geosites

Publication Date: 2025-01-01

Volume: 62

Issue: 4

Page Range: 2233-2239

Description:

The aim of the research is to explore the relationships between the different forms of active tourism and the service needs that arise, and the role of the use of information sources in the decision-making of active tourism participants. The closed-ended questionnaire survey investigated respondents' hiking habits, the services they use and the sources of information on active tourism. The questionnaire was completed by 169 people who had hiked in the Lake Velence area, their responses were analysed using SPSS and Excel programs. Cluster analysis was used to ide ntify different groups of active tourism participants, depending on the type of tours they prefer, the services they use and the sources of information they r ely on. ANOVA (one-way analysis of variance) was used to test whether different types of active tourism influence the use of services and to identify which services are most important for each group. In addition, a Pearson correlation matrix was constructed to show the relationships between each of the quantitative variables. The research contributes t o a better understanding of how different forms of active tourism and different information sources shape the service needs of active tourism participants, which can help to target the development of tourism services and the transition to the circular tour ism.

Open Access: Yes

DOI: 10.30892/gtg.62420-1586

Control of Local Tax Payments: A Comparative Law Case Study

Mariusz Popławski Bogumił Pahl Gábor Hulkó Tetiana Iefymenko

Publication Name: Bialostockie Studia Prawnicze

Publication Date: 2023-06-01

Volume: 28

Issue: 2

Page Range: 81-97

Description:

Tax payment is the basic form of fulfilling a tax obligation. It is included in the effective method of removing tax liabilities. As part of the control of payments of local taxes carried out by the tax authorities, it was found that an unauthorized employee of this authority unlawfully accepted payments of taxes that he did not pay to the account of the tax authority. A legal doubt has arisen in this respect as to whether the payment made in the above-mentioned circumstances is the payment of tax that gives rise to the removal of the tax liability. The main goal of the authors, within the research topic undertaken, is to verify the research hypothesis, according to which the taxpayer's transfer of funds to an unauthorized employee of a tax authority, confirmed by a receipt, cannot be considered as payment of the tax. The study analyzes the above-mentioned issues on the basis, above all, of the provisions of Polish tax law, which do not define the concept of tax payment, although they indicate the forms of payment. In order to get a broader perspective on the subject matter, the author analyzed selected regulations concerning the above-mentioned issues in Hungary and Ukraine.

Open Access: Yes

DOI: 10.15290/bsp.2023.28.02.06

Cross-country analysis of supply chain management drivers for small and medium-sized enterprises

Santi Setyaningsih Katalin Czakó Tihana Vasic Peter Kelle

Publication Name: Polish Journal of Management Studies

Publication Date: 2021-01-01

Volume: 23

Issue: 1

Page Range: 352-369

Description:

Supply Chain Management (SCM) drivers are the key factors in successful SCM strategy implementation. SMEs with limited resources need to focus on the top drivers to improve performance and competitiveness. The paper explores which driver factors have the largest importance according to the opinion of the top managers of SMEs. Two developing countries were compared which have different supply chain environments mainly due to their geographical structure. Information from top managers of 105 Hungarian and 124 Indonesian SMEs was collected using an online questionnaire. The data was analysed using statistical methods. This study is the first to rank SCM drivers in a quantitative study comparing SMEs in different supply chain environments. The findings reveal that from 22 driver factors both countries perceive the same top 10, however in a different ranking order. Improvement of customer satisfaction and information dissemination are the top two drivers, which are highly correlated.

Open Access: Yes

DOI: 10.17512/pjms.2021.23.1.22

Information Basis of Digital Twins: A Quantifiable Metric for Spatio-Temporal Expressivity

Adam Csapo Ildiko Horvath Norbert Szántó

Publication Name: Acta Polytechnica Hungarica

Publication Date: 2023-01-01

Volume: 20

Issue: 6

Page Range: 151-171

Description:

This paper focuses on the concept of Digital Twins and the characterization of Digital Twins in terms of the spatio-temporal extent of the information based on which they operate. Following an in-depth literature review, we observe that even when Digital Twins (and variations of this concept) are qualified in terms of ‘levels of information integration’, strictly quantifiable metrics are rarely applied. To fill this gap, we propose the term ‘information basis’, which highlights the quantifiable extent of events occurring in space and time which have an influence on the functionality of the Digital Twin. Following a discussion on the implications of this term, we present an example Digital Twin and discuss how its different alternative implementations would fall on different points of the newly introduced information basis spectrum.

Open Access: Yes

DOI: 10.12700/APH.20.6.2023.6.9