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Found 6423 publications

Myrsinane, Premyrsinane, and Cyclomyrsinane Diterpenes from Euphorbia falcata as Potassium Ion Channel Inhibitors with Selective G Protein-Activated Inwardly Rectifying Ion Channel (GIRK) Blocking Effects

Attila Csorba Péter Orvos G. Pinke László Tálosi Andrea Vasas Peter Forgo Judit Hohmann

Publication Name: Journal of Natural Products

Publication Date: 2016-08-26

Volume: 79

Issue: 8

Page Range: 1990-2004

Description:

GIRK channels are activated by a large number of G protein-coupled receptors and regulate the electrical activity of neurons, cardiac atrial myocytes, and β-pancreatic cells. Abnormalities in GIRK channel function have been implicated in the pathophysiology of neuropathic pain, drug addiction, and cardiac arrhythmias. In the heart, GIRK channels are selectively expressed in the atrium, and their activation inhibits pacemaker activity, thereby slowing the heart rate. In the present study, 19 new diterpenes, falcatins A-S (1-19), and the known euphorprolitherin D (20) were isolated from Euphorbia falcata. The compounds were assayed on stable transfected HEK-hERG (Kv11.1) and HEK-GIRK1/4 (Kir3.1 and Kir3.4) cells. Blocking activity on GIRK channels was exerted by 13 compounds (61-83% at 10 μM), and, among them, five possessed low potency on the hERG channel (4-20% at 10 μM). These selective activities suggest that myrsinane-related diterpenes are potential lead compounds for the treatment of atrial fibrillation.

Open Access: Yes

DOI: 10.1021/acs.jnatprod.6b00260

Multi-Physics thermal analysis of permanent magnets motors with exterior rotor

Lotfi Abdelhakim

Publication Name: Civil Comp Proceedings

Publication Date: 2015-01-01

Volume: 108

Issue: Unknown

Page Range: Unknown

Description:

This paper presents a magneto-thermal analysis of an external-rotor permanent magnet synchronous machine based on finite element method. The model developed can be used to predict the temperature distribution inside the motor during the rated operation. Electromagnetic computation is carried out with the aid of two twodimensional finite-element simulations of the cross-section of the permanent magnet motor [1]. In addition, the magnetic core losses of the stator and rotor are modelled based on the results from the electromagnetic analysis and a post-processing formula based on the loss-separation principle. To analyse the process of heat transfer in an electrical machine, empirical correlations are used to describe the convective heat transfer from the different surfaces of the permanent magnet motor. The heat transfer coefficients are determined using dimensionless numbers and the Nusselt number [2]. After the loss calculation, the temperatures of the machine are calculated using a three-dimensional finite element method. The results obtained from the model are compared with the experimental results from testing the prototype electric motor.

Open Access: Yes

DOI: DOI not available

Visualization and art in the mathematics classroom

Angela Schwenk Norbert Kalus Éva Veronika Rácz Gyor János Karsai

Publication Name: Zdm International Journal on Mathematics Education

Publication Date: 2003-12-01

Volume: 35

Issue: 1

Page Range: 24-29

Description:

In this paper we summarize our concepts and practice on computer-aided mathematical experimentation, and illustrate them by Mathematica projects that we have developed for our research and the courses "Computer-aided mathematical modelling" and "Computer Algebra I-II" held for students of life sciences at University of Szeged and computational engineering at TFH Berlin, University of Applied Sciences.

Open Access: Yes

DOI: DOI not available

Juvenile court – the Conqueror of Legal History

Enikő Kovács-Szépvölgyi

Publication Name: Journal on European History of Law

Publication Date: 2022-01-01

Volume: 13

Issue: 1

Page Range: 156-160

Description:

The idea of the title that the juvenile court is the greatest conqueror of legal history comes from a work by renowned criminal lawyer Ferenc Finkey, who quoted Hastings H. Hart’s thoughts about the juvenile court. The Juvenile Court first appeared in Illinois, USA, in 1899, followed by most federal states and several countries on the old continent. The state-and legal life of Hungary, in the broader context of the Central and Eastern European states, is usually interpreted in the framework of the centre-periphery model. Without going into the issue of regulatory delay, it is worth noting that Hungarian legislation caught up with pioneering states with special criminal law regulations introduced in the early 20th century to establish the foundations for other treatment of juvenile offenders. The different treatment in this context refers to different rules from those for adult offenders. The law regulating the juvenile court as a special court entered into force in 1914, supplementing the substantive criminal law provisions with procedural rules.

Open Access: Yes

DOI: DOI not available

Impact of Iron Loss on Performance of Speed Sensorless MRAS Estimator for Induction Machines

Krisztián Horváth Diána Henézi

Publication Name: 2022 22nd International Symposium on Electrical Apparatus and Technologies Siela 2022 Proceedings

Publication Date: 2022-01-01

Volume: Unknown

Issue: Unknown

Page Range: Unknown

Description:

In this work, the impact of iron loss on speed estimation performance of the conventional rotor flux error-based model reference adaptive system (MRAS) estimator is investigated in case of induction machines (IMs). In addition, two improved MRAS-type estimators are proposed to reduce the estimation error caused by iron loss. The first approach takes into account iron loss resistance by its nominal constant value. But in the second case, iron loss is frequency dependent. All three estimators are compared by simulations. The results show that the MRAS estimators with iron loss compensation can reduce the speed estimation error and the frequency dependent iron loss compensation method provides the highest accuracy.

Open Access: Yes

DOI: 10.1109/SIELA54794.2022.9845766

Cartel cases: From state negligence to direct political interest in Hungary

Tamás Bezsenyi Éva Inzelt

Publication Name: European White Collar Crime Exploring the Nature of European Realities

Publication Date: 2021-07-21

Volume: Unknown

Issue: Unknown

Page Range: 187-204

Description:

No description provided

Open Access: Yes

DOI: DOI not available

Mapping the scholarly literature on the infodemic using topic modelling

Gergely Ferenc Lendvai

Publication Name: Social Sciences and Humanities Open

Publication Date: 2026-06-01

Volume: 13

Issue: Unknown

Page Range: Unknown

Description:

The present study aims to map the scholarly evolution of the infodemic as a research subject through a scientometric analysis of 852 peer-reviewed articles indexed in Web of Science between 2020 and 2024 building on scientometric methods and Structural Topic Modeling (STM). Findings reveal a sharp rise in publications during the pandemic years, peaking in 2022, followed by a remarkable decline in both output and citation impact. The STM uncovered 20 distinct topics, with dominant themes centred on health communication, misinformation, social media, and institutional trust. While several themes peaked early in the pandemic, others, such as institutional or public trust, gained prominence later. Topic correlations showed dense interlinkages but low modularity suggested conceptual fragmentation and weak field consolidation. The results highlight that infodemic scholarship remains an emergent, interdisciplinary domain, however, there is a need for stable theoretical foundations.

Open Access: Yes

DOI: 10.1016/j.ssaho.2026.102572

Computer-Aided Planning of Radial and Diameter Routes in Local Public Transport Networks

Ágoston Winkler

Publication Name: Eurasia Proceedings of Science Technology Engineering and Mathematics

Publication Date: 2023-01-01

Volume: 23

Issue: Unknown

Page Range: 165-172

Description:

Local public transport network planning is a complex procedure affected by many aspects (e.g., city structure, travel needs, the budget for the service, vehicle types, service frequencies, timetable optimization of parallel routes etc.). Due to the high number of possible solutions, finding the optimum is usually a problem with NP computational complexity. Although an extensive toolkit is available for evaluating specific networks, the number of versions that can be realistically examined and compared is highly limited. This implies that the routine and creativity of the network planning specialists play an important role in the selection of the examined networks. However, in some special cases, the search space can be narrowed so that all network versions can be automatically generated and compared. This paper presents such a case: when applying radial and diameter routes only, the main question is which directions should be connected to each other as a diameter route, or left alone as a radial line. The algorithm is presented on the example of the city Győr.

Open Access: Yes

DOI: 10.55549/epstem.1365754

Laboratory Investigation on the Effect of Microsilica Additive on the Mechanical Behavior of Deep Soil Mixing Columns in Saline Dry Sand

Morteza Esmaeili Farshad Astaraki Majid Movahedi Rad Hamed Yaghouti

Publication Name: Periodica Polytechnica Civil Engineering

Publication Date: 2021-11-02

Volume: 65

Issue: 4

Page Range: 1080-1091

Description:

Since loose and salty subgrades consider as problematic barriers while constructing new transportation infrastructures such as railway tracks and roads are required, the current study aims to find a solution to stabilize these kinds of subgrades using the deep soil mixing (DSM) technique and micro silica additive. In the present study a series of experimental DSM columns were executed in a salty sand-filled chamber utilizing a laboratory scale DSM apparatuses. In the first step, by adding three salt percentages of 5, 10 and 20 into the original sand, four different sandy subgrades with a relative density of 70% were prepared. Considering three percentages of 10, 15 and 20 for micro silica additive, the water-to-cement ratio of 1, salt percentages of 0, 5, 10 and 20 totally 150 sand-cement columns were constructed in the lab environment. In continuation, unconfined compression strength (UCS) and elasticity modulus of all capped DSM columns have been determined and interpreted using scanning electron microscope (SEM) images at three ages of 7,14 and 28 days. The results indicated that increasing the salinity of subgrade soil from 0 to 20% resulted in a falling UCS and Young module by 28 and 21% for 28-days specimens. Furthermore, as a solution, adding micro silica in cement-water grout up to 15% resulted in enhancing mechanical characteristics of the DSM columns. So that adding 15% microsilica caused a 21 and 42% increase in UCS and elasticity modulus of 28-days samples respectively, executed in subgrade with 20% salt.

Open Access: Yes

DOI: 10.3311/PPci.18126