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Found 6289 publications

Altered dynamics may drift pathological fibrillization in membraneless organelles

N. Duro Boldizsar Tuu-Szabo G. Hoffka M. Fuxreiter

Publication Name: Biochimica Et Biophysica Acta Proteins and Proteomics

Publication Date: 2019-10-01

Volume: 1867

Issue: 10

Page Range: 988-998

Description:

Protein phase transition can generate non-membrane bound cellular compartments, which can convert from liquid-like to solid-like states. While the molecular driving forces of phase separation have been largely understood, much less is known about the mechanisms of material-state conversion. We apply a recently developed algorithm to describe the weak interaction network of multivalent motifs, and simulate the effect of pathological mutations. We demonstrate that linker dynamics is critical to the material-state of biomolecular condensates. We show that linker flexibility/mobility is a major regulator of the weak, heterogeneous meshwork of multivalent motifs, which promotes phase transition and maintains a liquid-like state. Decreasing linker dynamics increases the propensity of amyloid-like fragments via hampering the motif-exchange and reorganization of the weak interaction network. In contrast, increasing linker mobility may compensate rigidifying mutations, suggesting that the meshwork of weak, variable interactions may provide a rescue mechanism from aggregation. Motif affinity, on the other hand, has a moderate impact on fibrillization. Here we demonstrate that the fuzzy framework provides an efficient approach to handle the intricate organization of membraneless organelles, and could also be applicable to screen for pathological effects of mutations.

Open Access: Yes

DOI: 10.1016/j.bbapap.2019.04.005

Mediumship and its Cognitive 'Survival' in Identification of Collective Individuation : the Hungarian Painter-Genius Csontváry's Mediumship and 'Survival' Part I. on the Wailing Wall Picture of Csontváry

Peter Varlaki Judit Ida Steiner-Varlaki Péter Baranyi

Publication Name: 10th IEEE International Conference on Cognitive Infocommunications Coginfocom 2019 Proceedings

Publication Date: 2019-10-01

Volume: Unknown

Issue: Unknown

Page Range: 553-560

Description:

The paper deals with the mediumship and the retro-cognitive and precognitive patterns in identification of collective individuation. We attend to show the relationships between the artistic visions (pictures) of Csontváry the Hungarian genius and the dreams and active imaginations of C. G. Jung and W. Pauli by the identification of unconscious symbolic processes of collective individuation.11 This paper is dedicated to the blessed memory of Dr. Rezsö Pertorini and Dr. Anthony Storr. Thanks for the inspiration to Dr. Katalin Gellér.

Open Access: Yes

DOI: 10.1109/CogInfoCom47531.2019.9089946

Novel Pure-Pursuit Trajectory Following Approaches and their Practical Applications

Csaba Hajdu Ernö Horváth Péter Korös

Publication Name: 10th IEEE International Conference on Cognitive Infocommunications Coginfocom 2019 Proceedings

Publication Date: 2019-10-01

Volume: Unknown

Issue: Unknown

Page Range: 597-602

Description:

Pure-pursuit algorithm is a popular trajectory tracking algorithm, widely used in mobile robotics and vehicular control for numerous reasons. The operation is simple and straightforward as it depends only on the kinematic model of the target mechanical system. The algorithm can be tuned by choosing look-Ahead distance of points of the reference trajectory. On the other hand, pure-pursuit suffers from weaknesses highly attributed to improper selection of look-Ahead distance, resulting in poor tracking performance. Recent developments focused on overcoming this drawback by dynamical change of this parameter. In this paper, we propose three enhancements to the original pure-pursuit algorithm, aiming to handle dynamic selection of look-Ahead distance by selecting multiple goals, modifying look-Ahead distance according to the curvatures and adjusting lateral deviation. Our work was motivated by an ongoing autonomous vehicle research at our university.

Open Access: Yes

DOI: 10.1109/CogInfoCom47531.2019.9089927

Deep Metacyclic Parameter Search: Non-Convex optimization Based on Evolutionary Computing with a Few Twists

Adam B. Csapo

Publication Name: 10th IEEE International Conference on Cognitive Infocommunications Coginfocom 2019 Proceedings

Publication Date: 2019-10-01

Volume: Unknown

Issue: Unknown

Page Range: 247-252

Description:

This paper proposes a new framework for non-convex optimization referred to as Metacyclic Parameter Search (MEPS). The framework combines several approaches that are well known from the field of artificial intelligence-namely the iterative update of generations of candidate solutions prevalent in evolutionary computing and particle swarm optimization, as well as metacognitive approaches implementing reward-based improvement such as (deep) reinforcment learning-resulting in a gradient-free approach to non-convex optimization that combines the benefits (and alleviates the mutual shortcomings) of each of these individual approaches. Following an overview of the framework, its workings are demonstrated on three rudimentary examples.

Open Access: Yes

DOI: 10.1109/CogInfoCom47531.2019.9089907

Behaviors and Capabilities of Generation CE Students in 3D VR

Ildiko Horvath

Publication Name: 10th IEEE International Conference on Cognitive Infocommunications Coginfocom 2019 Proceedings

Publication Date: 2019-10-01

Volume: Unknown

Issue: Unknown

Page Range: 491-494

Description:

This study investigates the behaviors and habits shown by students of higher education while using MaxWhere's 3D VR spaces (www.maxwhere.com). Students participating in the study all belonged to the CE [2] generation or to slightly older (X and Y) generations. The study was based on a questionnaire survey and empirical research,-direct observations, with special focus on spatial awareness, collaboration, mobile applications, and cognitive processes-especially from the perspective of information processing. We paid attention to the techniques of perception of information, habits of information collection, selection, classification, and habits of applying and creating new information. Our study shows that those who study more than one smartboard content at the same time achieve better short-Term memorization and have better results in highlighting the essence of the topic at hand. Short and long-Term memorization are also influenced by the location of control questions relative to the theoretical content.

Open Access: Yes

DOI: 10.1109/CogInfoCom47531.2019.9089988

Mediumship and its Cognitive 'Survival' in Identification of Collective Individuation the Hungarian Painter-Genius Csontváry's Mediumship and 'Survival' Part II. The Hypothesis of Hidden Meaning System of the Picture

Peter Varlaki Judit Ida Steiner-Varlaki Péter Baranyi

Publication Name: 10th IEEE International Conference on Cognitive Infocommunications Coginfocom 2019 Proceedings

Publication Date: 2019-10-01

Volume: Unknown

Issue: Unknown

Page Range: 561-566

Description:

The paper deals with the mediumship and the retro-cognitive and precognitive patterns in identification of collective individuation. We attend to show the relationships between the artistic visions (pictures) of Csontváry the Hungarian genius. We continue the discussion with the general hidden mystical theological system of the picture11This paper is dedicated to the blessed memory of Dr. Rezsö Pertorini and Dr. Anthony Storr. Thanks for the inspiration to Dr. Katalin Gellér.

Open Access: Yes

DOI: 10.1109/CogInfoCom47531.2019.9089981

Use of foreign law in the practice of the Hungarian Constitutional Court - With special regard to the period between 2012 and 2016

Fanni Tanács-Mandák Csaba Erdos

Publication Name: Judicial Cosmopolitanism the Use of Foreign Law in Contemporary Constitutional Systems

Publication Date: 2019-09-24

Volume: Unknown

Issue: Unknown

Page Range: 618-649

Description:

No description provided

Open Access: Yes

DOI: 10.1163/9789004297593_025

Fabrication of waste bagasse fiber-reinforced epoxy composites: Study of physical, mechanical, and erosion properties

Amar Patnaik Gusztáv Fekete Sachin Tejyan Ibolya Zsoldos Vedant Singh Tej Singh

Publication Name: Polymer Composites

Publication Date: 2019-09-01

Volume: 40

Issue: 9

Page Range: 3777-3786

Description:

The aim of the research work is to study the physical, mechanical, and erosive wear properties of sugarcane bagasse fiber-reinforced epoxy composites. The physical (density, void content) and the mechanical (hardness, tensile strength, impact energy, flexural strength) properties of the composites were found to increase with the content of bagasse fiber. For erosive wear analysis, the experiments were carried out with the help of erosion test machine. To minimize the erosive wear rate, Taguchi technique is executed to explore the influence of five control factors including fiber content, impact velocity, impingement, stand-off distance, and erodent size at three levels. Using Taguchi (L27) orthogonal array, the optimal combination of control factors, which yielded minimum erosive wear rate, was statistically predicted and experimentally verified. The fiber content and impact velocity were the two most contributing control factors for the minimization of erosive wear rate. The important sequence of the parameters is fiber content > impact velocity > impingement angle > erodent size > stand-off distance. The optimal combination of control factors was obtained at 10 wt% of fiber content, 30 m/s of impact velocity, 30° of impingement angle, 85 mm of stand-off distance, and 250 μm of erodent size. Finally, composites worn surfaces were examined with scanning electron microscope to study the possible erosive wear mechanism. POLYM. COMPOS., 40:3777–3786, 2019. © 2019 Society of Plastics Engineers.

Open Access: Yes

DOI: 10.1002/pc.25239

Differences, constraints and key elements of providing local sharing economy services in different-sized cities: A Hungarian case

Katalin Czakó Dávid Fekete Kinga Szabó Marcell Tóth

Publication Name: Resources

Publication Date: 2019-09-01

Volume: 8

Issue: 3

Page Range: Unknown

Description:

The business models of sharing economy services can differ fromeach other in different-sized cities. This paper provides a deeper understanding of the implementation of locally operating services for car, bicycle and office sharing in the urban environment. Our goal is to reveal the differences between the capital city and an economically well-developed city in order to provide beneficial findings to the development of the presently operating services, or to the possible implementation of future services. Methodology of the paper applies the Business Model Canvas approach (BMC). We introduce a comparative analysis using data from the Hungarian database, which records details of all the publicly visible sharing economy services countrywide. The results show that BMC can reflect the main differences, constraints and key elements in the business models of sharing economy services. We can say that, in the case of a bike sharing service operated in the non-capital city, there is more segmentation than seen in the same service in the capital. There are significant price differences, especially in the case of long-term tickets. The number of inhabitants and private capital remain the biggest constraints in the case of car-sharing services, but there is also a possibility of implementation in the non-capital cities by applying small-scale services with a good value proposition and segmentation.

Open Access: Yes

DOI: 10.3390/resources8030147