Hansani Madushika Abeywickrama

57204445170

Publications - 2

Global, regional, and national burden of chronic kidney disease in adults, 1990–2023, and its attributable risk factors: a systematic analysis for the Global Burden of Disease Study 2023

Mohamad Amin Bakhshali Shoshana H. Ballew Ovidiu Constantin Baltatu Maciej Banach Mainak Bardhan Ahmed Abdelrahman Abdelgalil Saurav Basu Bekalu Mekonen Belay Makda Abate Belew Aminu K. Bello Luis Belo Amiel Nazer C. Bermudez Nurudeen A. Adegoke Fahmi Y. Al-Ashwal Nelson Alvis-Guzman Yaser Mohammed Al-Worafi Adel Sharaf Al-Zubairi Masoud Aman Mohammadi Hubert Amu Abhishek Anil Sajjad Ahmad Sulaimon O. Araromi Geminn Louis Carace Apostol Walter Appati Neeraj Bedi Rizwan Suliankatchi Abdulkader Filippos Anagnostakis Anayochukwu Edward Anyasodor Hiba Jawdat Barqawi Amir Mahmoud Ahmadzade Salah Al Awaidy Syed Shujait Ali Omar Almidani Hanadi Al Hamad Syed Mahfuz Al Hasan Karem H. Alzoubi Maha Moh'd Wahbi Atout Samar Abd Elhafeez Sajjad Ahmad Nesredin Ahmed Marjan Ajami Ayman Ahmed Salahdein Aburuz Yazan Al Thaher Ashagre Molla Assaye Khursheed Aurangzeb Adedapo Wasiu Awotidebe Domenico Azzolino Lucas Guimarães Abreu Bright Opoku Ahinkorah Qorinah Estiningtyas Sakilah Adnani Olugbenga Olusola Abiodun Hasan Aalruz Qorinah Estiningtyas Sakilah Adnani Bilyaminu Abubakar Isaac Yeboah Addo Qorinah Estiningtyas Sakilah Adnani Oyelola A. Adegboye Mohammad Mahdi Bastan Muhammad Badar Akshaya Srikanth Bhagavathula Sonu Bhaskar M. D.Abu Bashar Shahid Bashir Temitayo Esther Adeyeoluwa Johan Ärnlöv Bernard Kwadwo Yeboah Asiamah-Asare Hasan Aalruz Patrick B. Mark Lauryn K. Stafford Morgan E. Grams Hansani Madushika Abeywickrama Mohammed Mehdi Abrar Khabir Ahmad Ali Ahmadi Aram Mahmood Ahmed Priyadarshini Bhattacharjee Jasvinder Singh Bhatti Aleksandr Y. Aravkin Salahdein Aburuz Mohammed Z. Allouh Mohammadreza Akbari Oluwasefunmi Akeju Mohammed Ahmed Akkaif Ziyad Al-Aly Mohammed Albashtawy Shereen M. Aleidi Ali M. Alfalki Fadwa Naji Alhalaiqa Khalid A. Alhasan Endale Alemayehu Ali Rafat Ali Syed Yusuf Ali Mohammed Z. Allouh Maha Moh d.Wahbi Atout Wesam Taher Almagharbeh Sadat Abdulla Aziz Khaldoon Aied Alnawafleh Awais Altaf Samah W. Al-Jabi Najim Z. Alshahrani Jesu Arockiaraj Rizwan Suliankatchi Abdulkader Shahzaib Ahmed Syed Anees Ahmed Yuni Asri Ajay Nagesh Bhat Sadat Abdulla Aziz Dmitry Abramov

Publication Name: Lancet

Publication Date: 2025-11-22

Volume: 406

Issue: 10518

Page Range: 2461-2482

Description:

Background Chronic kidney disease (CKD) is common and ranks among the leading causes of mortality and morbidity. This analysis aimed to present global CKD estimates using the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023 to inform evidence-based policies for CKD identification and treatment. Methods This analysis focused on adults aged 20 years and older over the period 1990 to 2023, from 204 countries and territories. Data sources used were published literature, vital registration systems, kidney failure treatment registries, and household surveys. Estimates of CKD burden, including deaths, incidence, prevalence, and disability-adjusted life-years (DALYs), were produced using a Cause of Death Ensemble model and a Bayesian meta-regression analytical tool. A comparative risk assessment approach estimated the proportion of cardiovascular deaths attributable to impaired kidney function and estimated risk factors for CKD. Findings Globally, in 2023, 788 million (95% uncertainty interval 743–843) people aged 20 years and older were estimated to have CKD, up from 378 million (354–407) in 1990. The global age-standardised prevalence of CKD in adults was 14·2% (13·4–15·2), a relative rise of 3·5% (2·7–4·1) from 1990. The region with the highest age-standardised prevalence was north Africa and the Middle East (18·0%; 16·9–19·4). Most people had stage 1–3 CKD, with a combined prevalence of 13·9% (13·1–15·0). In 2023, CKD was the ninth leading cause of death globally, accounting for 1·48 million (1·30–1·65) deaths, and the 12th leading cause of DALYs, with an age-standardised DALY rate of 769·2 (691·8–857·4) per 100 000. Impaired kidney function as a risk factor accounted for 11·5% (8·4–14·5) of cardiovascular deaths. High fasting plasma glucose, body-mass index, and systolic blood pressure were all leading risk factors for CKD DALYs. Interpretation CKD is a major global health issue, with rising prevalence and increasing importance as a cause of death and as a risk factor for cardiovascular death. A better understating of aetiology, appropriate screening, and implementation programmes are needed to translate advances in CKD treatment into improved patient outcomes. Funding Gates Foundation, Wellcome, US National Kidney Foundation, and US National Institute of Diabetes and Digestive and Kidney Diseases.

Open Access: Yes

DOI: 10.1016/S0140-6736(25)01853-7

Global, regional, and national burden of road injuries 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023

Dariush Abtahi Meriem Abdoun Sami Saleh Alabdulwahab Siddig Ibrahim Abdelwahab Marjan Ajami Dari Alhuwail Victor Adekanmbi Fadwa Naji Alhalaiqa Auwal Abdullahi Ukachukwu O. Abaraogu Rana Kamal Abu Farha Isaac Yeboah Addo Shereen M. Aleidi Ahmad Y. Abuhelwa Irfan Ali Clifford Afoakwah Obed Adonteng-Kissi Sheikh Mohammad Alif Williams Agyemang-Duah Fuad Hamdi A. Abuadas Ali Ahmadi Stephanie C.C. van der Lubbe Fahmi Y. Al-Ashwal Ayman Ahmed Deldar Morad Abdulah Mahnaz Afshari Syed Mahfuz Al Hasan Danish Ahmad Mohammed Albashtawy Khurshid Alam Olumide Thomas Adeleke Mohamed Abouzid Hansani Madushika Abeywickrama Babatope Oluwadamilare Adebiyi Armita Abedi Dina Abushanab Muktar Beshir Ahmed Kamoru Ademola Adedokun A. Bhoomadevi Muayyad M. Ahmad Aqeel Ahmad Neda Akhoundi Miracle Ayomikun Adesina Hedayat Abbastabar Ebenezer Afrifa-Yamoah Fahad Mashhour Alanezi Tauseef Ahmad Abdul Momin Rizwan Ahmad Hasan Aalruz Niveen M.E. Abu-Rmeileh Muath A. Alammar Sajjad Ahmad Aanuoluwapo Adeyimika Afolabi Richard Gyan Aboagye Shreyash Agrawal Hussin Albargi Kamran Ali Nagah M. Abourashed Aiman P. Afsar Toufik Abdul-Rahman Shabbir Ahmed Mohammed Usman Ali Prince Owusu Adoma Madeline E. Moberg Hana J. Abukhadijah Abdullahi Tunde Aborode Khabir Ahmad Amani Alansari Salome Wumpini Agordoh Mehrunnisha Sharif Ahmed Zinat Abdrakhmanova Dolapo Emmanuel Ajala Aminu Kende Abubakar Hailey Lenox Tesfaye Birhanu Abebe Ashraf Alhumaidi Amidu Alhassan None Abdullah Aishah Fadila Adamu Apurba Acharya Mostafa Alam Teklebirhan Abrha Abrha Zahra Abbasi Dolatabadi Mohamed Sherif Ali Ahmed Tajudeen Adesanmi Adebisi Mohammad Ahmmad Mahmoud Al Zoubi Dominique Aluquin Mahdi Aghaalikhani Hasan Aalruz Haroon Ahmed Mohammad Shahid Ali Fahmi Y. Al-Ashwal Adekola George Adepoju Vijay K. Aggarwal Bhoomadevi A Mohammed Fasihul Alam Yawen Zhou Kiran Acharya Nagah M. Abourashed Salah Al Awaidy Olumide Abiodun Saira Afzal Mohammad Khursheed Alam Ali Ahmed

Publication Name: Lancet Public Health

Publication Date: 2026-01-01

Volume: Unknown

Issue: Unknown

Page Range: Unknown

Description:

Background Road injuries are a leading cause of mortality and morbidity worldwide. Years of international efforts have aimed to strengthen policy engagement, including the 2020 UN General Assembly's proclamation of the Second Decade of Action for Road Safety (2021–30), targeting a 50% reduction in road traffic deaths and serious injuries by 2030. The aim of this study is to provide estimates to monitor progress and identify intervention gaps. Methods As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2023, we estimated incidence, mortality, and morbidity of road injuries for 204 countries and territories from 1990 to 2023. Four road injury types and 47 nature-of-injury categories were examined. Morbidity and mortality data from clinical records, vital registration, and police reports were harmonised using meta-analytic techniques to ensure consistency and correct for systematic bias. Incidence was modelled with the meta-regression tool Disease Modelling-Meta-Regression version 2.1 and cause-specific mortality with the Cause of Death Ensemble model, both incorporating location-specific covariates to support interpolation. Years of life lived with disability (YLDs) were estimated from the prevalence and severity of the nature of road injury, and years of life lost (YLLs) from the number of cause-specific deaths multiplied by the standard life expectancy at the age of death. Disability-adjusted life-years (DALYs) were the sum of YLLs and YLDs. All metrics were calculated with 95% uncertainty intervals (UIs). Findings In 2023, there were 50·9 million (95% UI 46·1–56·1) road injury incident cases, 1·34 million (1·04–1·58) deaths, and 75·3 million (59·8–89·2) DALYs globally. Road injuries were the leading global cause of death among males aged 10–39 years. Between 1990 and 2023, age-standardised incidence decreased by 38·3% (95% UI 36·9–39·7) and mortality decreased by 32·3% (6·1–49·0), but progress varied widely by World Bank income group. Mortality in low-income countries (43·8 [95% UI 31·7–56·0] deaths per 100 000 population) was approximately six times higher than in high-income countries (7·5 [7·1–7·9] deaths per 100 000), despite the high-income countries showing the highest age-standardised incidence rates (858·1 [95% UI 781·9–947·1] cases per 100 000). In the past decade, many countries achieved notable reductions in road injuries, but others, including Ghana and the USA, saw increases. More severe injuries tended to occur in low-income and middle-income countries. Interpretation Although global incidence, mortality, and DALY rates from road injuries have declined, progress remains uneven, with pronounced disparities across income groups reflecting systemic inadequacies in infrastructure, vehicle standards, enforcement, and post-crash care. Strengthening emergency response, improving road design, enforcing safety measures, and adapting policies to the evolving demographics remain essential. Funding Gates Foundation.

Open Access: Yes

DOI: 10.1016/S2468-2667(26)00141-6