Shereen M. Aleidi

56459017600

Publications - 4

Global, regional, and national burden of chronic kidney disease in adults, 1990–2023, and its attributable risk factors: a systematic analysis for the Global Burden of Disease Study 2023

Mohamad Amin Bakhshali Shoshana H. Ballew Ovidiu Constantin Baltatu Maciej Banach Mainak Bardhan Ahmed Abdelrahman Abdelgalil Saurav Basu Bekalu Mekonen Belay Makda Abate Belew Aminu K. Bello Luis Belo Amiel Nazer C. Bermudez Nurudeen A. Adegoke Fahmi Y. Al-Ashwal Nelson Alvis-Guzman Yaser Mohammed Al-Worafi Adel Sharaf Al-Zubairi Masoud Aman Mohammadi Hubert Amu Abhishek Anil Sajjad Ahmad Sulaimon O. Araromi Geminn Louis Carace Apostol Walter Appati Neeraj Bedi Rizwan Suliankatchi Abdulkader Filippos Anagnostakis Anayochukwu Edward Anyasodor Hiba Jawdat Barqawi Amir Mahmoud Ahmadzade Salah Al Awaidy Syed Shujait Ali Omar Almidani Hanadi Al Hamad Syed Mahfuz Al Hasan Karem H. Alzoubi Maha Moh'd Wahbi Atout Samar Abd Elhafeez Sajjad Ahmad Nesredin Ahmed Marjan Ajami Ayman Ahmed Salahdein Aburuz Yazan Al Thaher Ashagre Molla Assaye Khursheed Aurangzeb Adedapo Wasiu Awotidebe Domenico Azzolino Lucas Guimarães Abreu Bright Opoku Ahinkorah Qorinah Estiningtyas Sakilah Adnani Olugbenga Olusola Abiodun Hasan Aalruz Qorinah Estiningtyas Sakilah Adnani Bilyaminu Abubakar Isaac Yeboah Addo Qorinah Estiningtyas Sakilah Adnani Oyelola A. Adegboye Mohammad Mahdi Bastan Muhammad Badar Akshaya Srikanth Bhagavathula Sonu Bhaskar M. D.Abu Bashar Shahid Bashir Temitayo Esther Adeyeoluwa Johan Ärnlöv Bernard Kwadwo Yeboah Asiamah-Asare Hasan Aalruz Patrick B. Mark Lauryn K. Stafford Morgan E. Grams Hansani Madushika Abeywickrama Mohammed Mehdi Abrar Khabir Ahmad Ali Ahmadi Aram Mahmood Ahmed Priyadarshini Bhattacharjee Jasvinder Singh Bhatti Aleksandr Y. Aravkin Salahdein Aburuz Mohammed Z. Allouh Mohammadreza Akbari Oluwasefunmi Akeju Mohammed Ahmed Akkaif Ziyad Al-Aly Mohammed Albashtawy Shereen M. Aleidi Ali M. Alfalki Fadwa Naji Alhalaiqa Khalid A. Alhasan Endale Alemayehu Ali Rafat Ali Syed Yusuf Ali Mohammed Z. Allouh Maha Moh d.Wahbi Atout Wesam Taher Almagharbeh Sadat Abdulla Aziz Khaldoon Aied Alnawafleh Awais Altaf Samah W. Al-Jabi Najim Z. Alshahrani Jesu Arockiaraj Rizwan Suliankatchi Abdulkader Shahzaib Ahmed Syed Anees Ahmed Yuni Asri Ajay Nagesh Bhat Sadat Abdulla Aziz Dmitry Abramov

Publication Name: Lancet

Publication Date: 2025-11-22

Volume: 406

Issue: 10518

Page Range: 2461-2482

Description:

Background Chronic kidney disease (CKD) is common and ranks among the leading causes of mortality and morbidity. This analysis aimed to present global CKD estimates using the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023 to inform evidence-based policies for CKD identification and treatment. Methods This analysis focused on adults aged 20 years and older over the period 1990 to 2023, from 204 countries and territories. Data sources used were published literature, vital registration systems, kidney failure treatment registries, and household surveys. Estimates of CKD burden, including deaths, incidence, prevalence, and disability-adjusted life-years (DALYs), were produced using a Cause of Death Ensemble model and a Bayesian meta-regression analytical tool. A comparative risk assessment approach estimated the proportion of cardiovascular deaths attributable to impaired kidney function and estimated risk factors for CKD. Findings Globally, in 2023, 788 million (95% uncertainty interval 743–843) people aged 20 years and older were estimated to have CKD, up from 378 million (354–407) in 1990. The global age-standardised prevalence of CKD in adults was 14·2% (13·4–15·2), a relative rise of 3·5% (2·7–4·1) from 1990. The region with the highest age-standardised prevalence was north Africa and the Middle East (18·0%; 16·9–19·4). Most people had stage 1–3 CKD, with a combined prevalence of 13·9% (13·1–15·0). In 2023, CKD was the ninth leading cause of death globally, accounting for 1·48 million (1·30–1·65) deaths, and the 12th leading cause of DALYs, with an age-standardised DALY rate of 769·2 (691·8–857·4) per 100 000. Impaired kidney function as a risk factor accounted for 11·5% (8·4–14·5) of cardiovascular deaths. High fasting plasma glucose, body-mass index, and systolic blood pressure were all leading risk factors for CKD DALYs. Interpretation CKD is a major global health issue, with rising prevalence and increasing importance as a cause of death and as a risk factor for cardiovascular death. A better understating of aetiology, appropriate screening, and implementation programmes are needed to translate advances in CKD treatment into improved patient outcomes. Funding Gates Foundation, Wellcome, US National Kidney Foundation, and US National Institute of Diabetes and Digestive and Kidney Diseases.

Open Access: Yes

DOI: 10.1016/S0140-6736(25)01853-7

Disease burden attributable to intimate partner violence against females and sexual violence against children in 204 countries and territories, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023

Amani Alansari Rana Kamal Abu Farha Haroon Ahmed Kamoru Ademola Adedokun Nurudeen A. Adegoke Aanuoluwapo Adeyimika Afolabi Lisa C. Adams Muayyad M. Ahmad Mesfin Abebe Armita Abedi Hubert Amu Aqeel Ahmad Anayochukwu Edward Anyasodor Mohmmad Minwer Alnaeem Alemwork Abie Muhammad Sohail Afzal Danish Ahmad Rotimi Felix Afolabi Saira Afzal Seyyed Shamsadin Athari Samar Abd Elhafeez Mehrunnisha Sharif Ahmed Ayman Ahmed Meriem Abdoun Zufishan Alam Lucas Guimarães Abreu Bright Opoku Ahinkorah Qorinah Estiningtyas Sakilah Adnani Haroon Ahmed Roberto Ariel Abeldaño Zuñiga Asma Ahmed Meshack Achore Hasan Aalruz Bilyaminu Abubakar Sawsan Abuhammad Olumide Abiodun Richard Gyan Aboagye Habeeb Omoponle Adewuyi Mohammad Mahdi Bastan M. D.Abu Bashar Oluwatobi E. Adegbile Olumide Thomas Adeleke Shahid Bashir Miracle Ayomikun Adesina Leticia Akua Adzigbli Hasan Aalruz Aleksandr Y. Aravkin Roberto Ariel Abeldaño Zuñiga Montaha Al-Iede Intima Alrimawi Saeid Anvari Shereen M. Aleidi Md Al-Mamun Hamid Alinejad Rokny Fadwa Naji Alhalaiqa Joseph Uy Almazan Mohmmad Minwer Alnaeem Mohammad Sharif Ibrahim Alyahya Tarek Tawfik Amin Luisa S. Flor Saeed Amini Sohrab Amiri Jimoh Amzat David B. Anderson Boluwatife Stephen Anuoluwa Siddig Ibrahim Abdelwahab Babatope Oluwadamilare Adebiyi Makinde Adebayo Adeniyi Asma Ahmed Cory N. Spencer Jack Cagney Gabriela Fernanda Gil Yonas Abebe Oli Ahmed Elizabeth Oluwatoyin Akin-Odanye Wole Akosile Idorenyin Ubon Akpabio Rasmieh Mustafa Al-Amer Turki M. Alanzi Melaku Birhanu Alemu Jorge Arias de la Torre Benedetta Armocida Alejandra Arrieta Wesam Taher Almagharbeh Deepavalli Arumuganainar Bilal Aslam Prince Atorkey Sachin R. Atre Abadi Hailay Atsbaha Madhu Sudhan Atteraya Ahmed Y. Azzam Khlood K. Baghlaf B. Sheeba Najim Z. Alshahrani Jose Balmori-de-la-Miyar Soham Bandyopadhyay Julie Alaere Atta Asma Ahmed Atif Amin Baig Manish Barik Suzanne Lyn Barker-Collo Azadeh Bashiri Tahira Ashraf Yuni Asri B. Sheeba Wondu Feyisa Balcha Williams Agyemang-Duah Md Al-Mamun

Publication Name: Lancet

Publication Date: 2026-01-03

Volume: 407

Issue: 10523

Page Range: 31-52

Description:

Background Violence against women and against children are human rights violations with lasting harms to survivors and societies at large. Intimate partner violence (IPV) and sexual violence against children (SVAC) are two major forms of such abuse. Despite their wide-reaching effects on individual and community health, these risk factors have not been adequately prioritised as key drivers of global health burden. Comprehensive x§and reliable estimates of the comparative health burden of IPV and SVAC are urgently needed to inform investments in prevention and support for survivors at both national and global levels. Methods We estimated the prevalence and attributable burden of IPV among females and SVAC among males and females for 204 countries and territories, by age and sex, from 1990 to 2023, as part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2023. We searched several global databases for data on self-reported exposure to IPV and SVAC and undertook a systematic review to identify the health outcomes associated with each of these risk factors. We modelled IPV and SVAC prevalence using spatiotemporal Gaussian process regression, applying data adjustments to account for measurement heterogeneity. We employed burden-of-proof methodology to estimate relative risks for outcomes associated with IPV and SVAC. These estimates informed the calculation of population attributable fractions, which were then used to quantify disability-adjusted life-years (DALYs) attributable to each risk factor. Findings Globally, in 2023, we estimated that 608 million (95% uncertainty interval 518–724) females aged 15 years and older had ever been exposed to IPV, and 1·01 billion (0·764–1·48) individuals aged 15 years and older had experienced sexual violence during childhood. 18·5 million (8·74–30·0) DALYs were attributed to IPV among females and 32·2 million (16·4–52·5) DALYs were attributed to SVAC among males and females in 2023. IPV and SVAC were among the top contributors to the global disease burden in 2023, particularly among females aged 15–49 years, ranking as the fourth and fifth leading risk factors, respectively, for DALYs in this group. Among the eight health outcomes found to be associated with IPV, anxiety disorders and major depressive disorder were the leading causes of IPV-attributed DALYs, accounting for 5·43 million (–1·25 to 14·6) and 3·96 million (1·71 to 6·92) DALYs in 2023, respectively. SVAC was associated with 14 health outcomes, including mental health disorder, substance use disorder, and chronic and infectious disease outcomes. Self-harm and schizophrenia were the leading causes of SVAC-attributed burden, with SVAC accounting for 6·71 million (2·00 to 12·7) DALYs due to self-harm and 4·15 million (–1·92 to 13·1) DALYs due to schizophrenia in 2023. Interpretation IPV and SVAC are substantial contributors to global health burden, and their health consequences span a variety of individual health outcomes. Importantly, mental health disorders account for the greatest share of disease burden among survivors. Investing in prevention of these avoidable risk factors has the potential to avert millions of DALYs and considerable premature mortality each year. Our findings represent strong evidence for global and national leaders to elevate IPV and SVAC among public health priorities. Sustained investments are needed to prevent IPV and SVAC and to implement interventions focused on supporting the complex social and health needs of survivors. Funding Gates Foundation.

Open Access: Yes

DOI: 10.1016/S0140-6736(25)02503-6

Global, regional, and national sepsis incidence and mortality, 1990–2021: a systematic analysis

Usha Adiga Samah W. Al-Jabi Meriem Abdoun Quique Bassat Zulfiqar A. Bhutta Hany Aly Ashish Bhargava Hasan Yaser Alniss Razique Anwer Abdul Monim Batiha Asrat Agalu Abejew Samar Abd Elhafeez Mahwish Arooj Matteo Bauckneht Mohammad R. Alqudimat Alok Atreya Abdelazeem M. Algammal Saeid Anvari Auwal Abdullahi Tahira Ashraf Shereen M. Aleidi Mohammad R. Alosta Senthilkumar Balakrishnan Zarrin Basharat Montaha Al-Iede Nasir Abbas Syed Shujait Ali Williams Agyemang-Duah Sahel Majed Alrousan Lucien R. Swetschinski Sonu Bhaskar Anayochukwu Edward Anyasodor Lisa C. Adams Ahmad Naoras Bitar Madineh Abbasi Habib Benzian Intima Alrimawi Nicole Davis Weaver Mohammed Albashtawy Meshack Achore Domenico Azzolino Eve E. Wool Kamoru Ademola Adedokun Fahad A. Alhumaydhi Ahmad Alrawashdeh Aqeel Ahmad Simachew Animen Bante Nelson Alvis-Guzman Umar Muhammad Bello Rafat Ali Kevin S. Ikuta Qorinah Estiningtyas Sakilah Adnani Rajon Banik Amadou Barrow Mina Borran Wondu Feyisa Balcha Chieh Han Gasha Salih Ahmed Aanuoluwapo Adeyimika Afolabi Alaa Aboelnour Badran Anna Gershberg Hayoon Hamed Borhany Nikha Bhardwaj Ahmad Rajeh Al-Qudimat Najim Z. Alshahrani Fentahun Alemnew Mesfin Abebe Md Akib Al-Zubayer Ema Akter Ridwan Olamilekan Adesola Ali Azargoonjahromi Authia P. Gray Mahsa Ahadi Mohammed Usman Ali Zelalem Asmare Hana J. Abukhadijah Alemwork Abie Amani Alansari Asnake Gashaw Belayneh Yaser Mohammed Al-Worafi Filippos Anagnostakis Daniel T. Araki Hassan Abolhassani Sabah Al-Marwani Gokce Belge Bilgin Mohammad Mahdi Bastan Meqdad Saleh Ahmed Rebecca L. Hsu Abiye Assefa Berihun Erin Chung Hiba Jawdat Barqawi Julie Alaere Atta Nurila Aryntayeva Wakgari Mosisa Abdisa Qorinah Estiningtyas Sakilah Adnani Redeat Libanos Assefa Syed Anees Ahmed Haroon Ahmed Sadat Abdulla Aziz Avinash Aujayeb Tomislav Mestrovic

Publication Name: Lancet Global Health

Publication Date: 2025-12-01

Volume: 13

Issue: 12

Page Range: e2013-e2026

Description:

Background: The global burden of sepsis, a life-threatening dysregulated host response to infection leading to organ dysfunction, remains challenging to quantify. We aimed to comprehensively estimate the global, regional, and national burden of sepsis, including the impact of the COVID-19 pandemic and underlying causes of sepsis-related deaths with co-occurring infectious syndromes. Methods: We used multiple cause-of-death, hospital, minimally invasive tissue sampling, and linked death certificate and hospital record data representing 149 million deaths, covering 4290 location-years with mortality estimates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 to capture explicit and implicit sepsis cases and deaths. We estimated age-location-sex-specific fractions of sepsis-related deaths from 195 underlying causes of death and 22 infectious syndromes from 1990 to 2021 using binomial logistic regression models, and estimated sepsis-related deaths using GBD cause-specific mortality estimates. Using 250 million hospital admissions and 7·82 million deaths from hospital data, representing 1310 location-years, we modelled case fatality rates by use of binomial logistic regression, applied to sepsis death estimates to estimate sepsis incidence by age, location, and year. Findings: In 2021, we estimated 166 million (95% uncertainty interval 135–201) sepsis cases and 21·4 million (20·3–22·5) all-cause sepsis-related deaths globally, representing 31·5% of total global deaths. Sepsis-related deaths decreased between 1990 and 2019, followed by a surge in 2020 and 2021. As of 2021, individuals aged 15 years and older experienced increases across incidence (230%) and mortality (26·3%) since 1990. Those aged 70 years and older had the highest sepsis-related mortality in 2021 (9·28 million [8·74–9·86] deaths). Sepsis-related deaths from infectious underlying causes decreased from 11·8 million (11·1–12·5) in 1990 to 8·34 million (7·72–9·01) in 2019, then increased by 86·4% to 15·5 million (14·7–16·4) in 2021. Sepsis-related mortality due to non-infectious underlying causes of death increased from 4·69 million (4·35–5·05) in 1990 to 5·81 million (5·40–6·25) in 2021; the leading non-infectious underlying causes of death with sepsis were stroke, chronic obstructive pulmonary disease, and cirrhosis. In 2021, bloodstream infections inclusive of HIV and malaria (3·08 million [2·83–3·35]) and lower respiratory infections inclusive of COVID-19 (11·33 million [1·20–1·47]) were the most prominent infectious syndromes complicating sepsis-related deaths from non-infectious underlying causes, representing a consistent trend since 1990. Interpretation: The global burden of sepsis increased in 2020 and 2021, reversing progress from 1990. Sepsis incidence and mortality increased in people aged 15 years and older, especially those aged 70 years and older, and as a complication of non-infectious underlying causes of death such as stroke, primarily through bloodstream infections and lower respiratory infections. The global burden of sepsis is substantial, and sepsis is increasingly a complication of non-infectious causes of death. Funding: Gates Foundation, Wellcome Trust, and Department of Health and Social Care using UK aid funding managed by the Fleming Fund.

Open Access: Yes

DOI: 10.1016/S2214-109X(25)00356-0

Global, regional, and national burden of road injuries 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023

Dariush Abtahi Meriem Abdoun Sami Saleh Alabdulwahab Siddig Ibrahim Abdelwahab Marjan Ajami Dari Alhuwail Victor Adekanmbi Fadwa Naji Alhalaiqa Auwal Abdullahi Ukachukwu O. Abaraogu Rana Kamal Abu Farha Isaac Yeboah Addo Shereen M. Aleidi Ahmad Y. Abuhelwa Irfan Ali Clifford Afoakwah Obed Adonteng-Kissi Sheikh Mohammad Alif Williams Agyemang-Duah Fuad Hamdi A. Abuadas Ali Ahmadi Stephanie C.C. van der Lubbe Fahmi Y. Al-Ashwal Ayman Ahmed Deldar Morad Abdulah Mahnaz Afshari Syed Mahfuz Al Hasan Danish Ahmad Mohammed Albashtawy Khurshid Alam Olumide Thomas Adeleke Mohamed Abouzid Hansani Madushika Abeywickrama Babatope Oluwadamilare Adebiyi Armita Abedi Dina Abushanab Muktar Beshir Ahmed Kamoru Ademola Adedokun A. Bhoomadevi Muayyad M. Ahmad Aqeel Ahmad Neda Akhoundi Miracle Ayomikun Adesina Hedayat Abbastabar Ebenezer Afrifa-Yamoah Fahad Mashhour Alanezi Tauseef Ahmad Abdul Momin Rizwan Ahmad Hasan Aalruz Niveen M.E. Abu-Rmeileh Muath A. Alammar Sajjad Ahmad Aanuoluwapo Adeyimika Afolabi Richard Gyan Aboagye Shreyash Agrawal Hussin Albargi Kamran Ali Nagah M. Abourashed Aiman P. Afsar Toufik Abdul-Rahman Shabbir Ahmed Mohammed Usman Ali Prince Owusu Adoma Madeline E. Moberg Hana J. Abukhadijah Abdullahi Tunde Aborode Khabir Ahmad Amani Alansari Salome Wumpini Agordoh Mehrunnisha Sharif Ahmed Zinat Abdrakhmanova Dolapo Emmanuel Ajala Aminu Kende Abubakar Hailey Lenox Tesfaye Birhanu Abebe Ashraf Alhumaidi Amidu Alhassan None Abdullah Aishah Fadila Adamu Apurba Acharya Mostafa Alam Teklebirhan Abrha Abrha Zahra Abbasi Dolatabadi Mohamed Sherif Ali Ahmed Tajudeen Adesanmi Adebisi Mohammad Ahmmad Mahmoud Al Zoubi Dominique Aluquin Mahdi Aghaalikhani Hasan Aalruz Haroon Ahmed Mohammad Shahid Ali Fahmi Y. Al-Ashwal Adekola George Adepoju Vijay K. Aggarwal Bhoomadevi A Mohammed Fasihul Alam Yawen Zhou Kiran Acharya Nagah M. Abourashed Salah Al Awaidy Olumide Abiodun Saira Afzal Mohammad Khursheed Alam Ali Ahmed

Publication Name: Lancet Public Health

Publication Date: 2026-01-01

Volume: Unknown

Issue: Unknown

Page Range: Unknown

Description:

Background Road injuries are a leading cause of mortality and morbidity worldwide. Years of international efforts have aimed to strengthen policy engagement, including the 2020 UN General Assembly's proclamation of the Second Decade of Action for Road Safety (2021–30), targeting a 50% reduction in road traffic deaths and serious injuries by 2030. The aim of this study is to provide estimates to monitor progress and identify intervention gaps. Methods As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2023, we estimated incidence, mortality, and morbidity of road injuries for 204 countries and territories from 1990 to 2023. Four road injury types and 47 nature-of-injury categories were examined. Morbidity and mortality data from clinical records, vital registration, and police reports were harmonised using meta-analytic techniques to ensure consistency and correct for systematic bias. Incidence was modelled with the meta-regression tool Disease Modelling-Meta-Regression version 2.1 and cause-specific mortality with the Cause of Death Ensemble model, both incorporating location-specific covariates to support interpolation. Years of life lived with disability (YLDs) were estimated from the prevalence and severity of the nature of road injury, and years of life lost (YLLs) from the number of cause-specific deaths multiplied by the standard life expectancy at the age of death. Disability-adjusted life-years (DALYs) were the sum of YLLs and YLDs. All metrics were calculated with 95% uncertainty intervals (UIs). Findings In 2023, there were 50·9 million (95% UI 46·1–56·1) road injury incident cases, 1·34 million (1·04–1·58) deaths, and 75·3 million (59·8–89·2) DALYs globally. Road injuries were the leading global cause of death among males aged 10–39 years. Between 1990 and 2023, age-standardised incidence decreased by 38·3% (95% UI 36·9–39·7) and mortality decreased by 32·3% (6·1–49·0), but progress varied widely by World Bank income group. Mortality in low-income countries (43·8 [95% UI 31·7–56·0] deaths per 100 000 population) was approximately six times higher than in high-income countries (7·5 [7·1–7·9] deaths per 100 000), despite the high-income countries showing the highest age-standardised incidence rates (858·1 [95% UI 781·9–947·1] cases per 100 000). In the past decade, many countries achieved notable reductions in road injuries, but others, including Ghana and the USA, saw increases. More severe injuries tended to occur in low-income and middle-income countries. Interpretation Although global incidence, mortality, and DALY rates from road injuries have declined, progress remains uneven, with pronounced disparities across income groups reflecting systemic inadequacies in infrastructure, vehicle standards, enforcement, and post-crash care. Strengthening emergency response, improving road design, enforcing safety measures, and adapting policies to the evolving demographics remain essential. Funding Gates Foundation.

Open Access: Yes

DOI: 10.1016/S2468-2667(26)00141-6