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Exhaustive enumeration of heat exchanger networks with minimum utility consumption using graph-theoretic approach

Publication Name: Energy

Publication Date: 2025-10-30

Volume: 335

Issue: Unknown

Page Range: Unknown

Description:

Enhancement in energy recovery is always an essential element that requires academic spotlights to ensure its capability to contribute towards carbon neutrality. Recent works have extended to cover multi-solution heat exchanger networks (HEN) synthesis instead of generating a single best solution, which is not guaranteed to be practical. Nevertheless, owing to the technical challenges of synthesising all feasible networks, none of the existing works attempts to comprehensively elucidate how network topologies affect the network cost. To address this gap, P-HENS, a graph theoretic-based HEN synthesis tool, was utilised to generate the set of all heat exchanger networks with minimum utility consumption. Its effectiveness is demonstrated through an illustrative case study, which eventually generates more than 45,000 HENs. The impacts of structural variables on the cost, including the number of exchangers and the stream pairings, were analysed. The cost range of the networks was identified, revealing cost differences of 30 % despite minimum utility consumption or 15 % despite the minimum number of exchangers. Key stream pairs required to meet maximum energy recovery and influence cost were identified, leading to recommendations for improving solution searches. The solution set and the insight from this work are available to the research community for further analysis, offering valuable insights to enhance energy integration in the industry.

Open Access: Yes

DOI: 10.1016/j.energy.2025.137898

Equation-oriented thermodynamic optimisation of heat pump integration in industrial heat recovery systems: A system-level pathway to cost and emission reduction

Publication Name: Energy

Publication Date: 2025-10-30

Volume: 335

Issue: Unknown

Page Range: Unknown

Description:

Integrating heat pumps into large-scale electricity-to-heat industrial processes has proven highly successful in enhancing the utilisation of renewable energy and contributing to carbon emission reductions. However, most studies focus on overall system performance, overlooking the detailed thermal behaviour of the heat pump itself. This limits the adaptability of heat pumps in dynamic industrial settings. This work proposes an equation-oriented framework that enables flexible integration of thermodynamically detailed heat pump models into industrial heat recovery systems. A superstructure-based optimisation model is developed to minimise energy costs and enhance efficiency, considering process constraints, network layout, and heat pump performance. The model dynamically optimises heat pump operation and placement to enhance waste heat recovery and overall system integration. Moreover, the approach supports the integration of low-grade utilities to further improve the energy efficiency. The proposed framework is validated through an industrial-scale case study of a crude oil distillation process. Life cycle assessment is conducted to quantify potential environmental and economic benefits. Results show that integrating heat pumps into the system recovered 50.52 % of low-pressure steam, reducing the total operating cost and annual cost by 12.88 % and 12.42 %. Additionally, total net carbon emissions decreased by 28.70 %. Lower electricity prices increase heat pump use and economic benefits but also amplify rebound effects. Furthermore, although high-temperature heat pumps operating above 150 °C tend to increase capital expenditures, they unlock greater energy efficiency, thereby accelerating the industrial decarbonisation process.

Open Access: Yes

DOI: 10.1016/j.energy.2025.137936

Corruption Perception in the Light of Green Transition Indicators

Publication Name: Sustainable Development and Green Innovation Managing Risk Through Interdisciplinary Approaches and Policy Strategies

Publication Date: 2025-10-27

Volume: Unknown

Issue: Unknown

Page Range: 219-236

Description:

Purpose: This study explores the relationship between green transition areas that promote sustainability and the perceived level of corruption across 41 countries. Need for the study: Corruption undermines sustainability efforts and environmental governance, creating a need to understand its interaction with green transition indicators. Methodology: The study uses data from the Bertelsmann Stiftung (BS) Sustainable Governance Indicators (SGI) 2022 report and Transparency International's Corruption Perceptions Index (CPI), deploying statistical methods to examine how environmental policy and participation in international treaties affect corruption. Findings: State performance in environmental policy significantly influences corruption perception, with effects enhanced by international cooperation. Gross greenhouse gas emissions emerge as the most influential indicator, negatively affecting corruption perception by increasing its presence. Practical implications: These findings call for integrating anti-corruption measures into environmental policy frameworks, fostering international collaboration, and enhancing transparency to advance sustainable development and reduce corruption risks.

Open Access: Yes

DOI: 10.1108/978-1-83608-462-420251010

Acoustic fingerprint in vehicle manufacturing as a basis for future applications

Publication Name: Pollack Periodica

Publication Date: 2025-10-27

Volume: 20

Issue: 3

Page Range: 82-87

Description:

The spread of new energy vehicles has opened a new chapter in premium-class acoustics. In e-mode, hitherto inaudible noises – suppressed by traditional engines – have become audible. Therefore, it is necessary to make subjective noises objective. The first step is to make them comparable by measuring. The result of the sum of these spectrograms is an acoustic fingerprint of the vehicle.The next step is to add them to a database. Early failure prediction and the avoidance of redundant service activities by using automated event detection led to financial savings. Data processing with machine learning opens space for car workshop support applications, and it is also possible to prevent critical failures that may begin with the help of predictive models (predictive service).

Open Access: Yes

DOI: 10.1556/606.2025.01260

Solar park at the water supplier

Publication Name: Pollack Periodica

Publication Date: 2025-10-27

Volume: 20

Issue: 3

Page Range: 140-146

Description:

The experience proves that solar power installations worldwide are growing rapidly. Renewable energy sources other one as solar energy has the potential to reduce the ecological footprint. The converter that utilizes renewable energy technologies and methods are constantly evolving with their spread, purchasing goods are becoming more and more favorable. In this study the measurement of the time period March 1–31 is presented at a waterworks. During the measurement, hourly recordings were taken. During the study, load power, generated power, grid power, specific electricity consumption, electricity consumed distribution, and the energy cost were determined.

Open Access: Yes

DOI: 10.1556/606.2025.01281

Preface on "Natural hazards' impact on natural and built heritage and infrastructure in urban and rural zones"

Publication Name: Natural Hazards and Earth System Sciences

Publication Date: 2025-10-27

Volume: 25

Issue: 10

Page Range: 4181-4183

Description:

This is an overview of the papers published in the special issue.

Open Access: Yes

DOI: 10.5194/nhess-25-4181-2025

Managing soil health for climate resilience and crop productivity in a changing environment

Publication Name: Science of the Total Environment

Publication Date: 2025-10-20

Volume: 1000

Issue: Unknown

Page Range: Unknown

Description:

Healthy soil is essential for life on Earth, valued for its ability to sustain productivity, provide ecosystem services, support biodiversity, socioeconomic structure, food security, and promote environmental health. However, climate-induced changes, such as extreme weather events, shifting precipitation patterns, and rising temperatures, can disrupt essential soil processes. Climate change, combined with unsustainable soil management practices, can accelerate soil degradation, loss soil organic matter, reduce soil moisture retention, intensify erosion, disrupt nutrient cycling, and increase greenhouse gas emission. An increase in temperature of 1 °C is estimated to increase pest incidence by 10–25 % and reduce major crop yields by up to 7.4 %. Enhancing soil health strengthens plant resilience, suppresses disease development, and safeguards agroecosystems against the adverse effects of climate extremes. The growing recognition of the central role of soil in both agricultural and environmental sustainability has therefore driven interest in holistic strategies that integrate advanced agronomic practices, innovative technologies, and enabling policy frameworks to sustainably manage and restore soil health. This review examines recent advances in soil management strategies, highlighting the integration of interdisciplinary approaches to strengthen soil health as a basis for climate change resilience and increased crop productivity. Our synthesis emphasizes the importance of tailoring agricultural management practices such as soil amendments, diverse cropping systems, beneficial microbes, conservation agriculture, precision agriculture, and innovative technologies to specific soil and environmental contexts. By adopting these strategies through an interdisciplinary approach, we can improve soil productivity, sustain agroecosystem functions, and mitigate negative environmental impacts, ensuring the capacity of soil to meet the demands of a changing world.

Open Access: Yes

DOI: 10.1016/j.scitotenv.2025.180460

Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023

Simon I. Hay Kanyin Liane Ong Damian F. Santomauro A. Bhoomadevi Mohammad Amin Aalipour Hasan Aalruz Hazim S. Ababneh Ukachukwu O. Abaraogu Biruk Beletew Abate Cristiana Abbafati Nasir Abbas Mitra Abbasifard Mohsen Abbasi-Kangevari Samar Abd ElHafeez Ashraf Nabiel Abdalla Mohammed Altigani Abdalla Emad M. Abdallah Barkhad Aden Abdeeq Nadin M.I. Abdel Razeq Ahmed Abdelrahman Abdelgalil Reda Abdel-Hameed Michael Abdelmasseh Mahmoud Abdelnabi Wael M. Abdel-Rahman Sherief Abd-Elsalam Sepideh Abdi Mohammad Abdollahi Meriem Abdoun Arman Abdous Jeza Muhamad Abdul Aziz Deldar Morad Abdulah Rizwan Suliankatchi Abdulkader Adam Abdullahi Auwal Abdullahi Toufik Abdul-Rahman Kulmira Abdykerimova Habtamu Abebe Getahun Aidin Abedi Armita Abedi Asrat Agalu Abejew Roberto Ariel Abeldaño Zuñiga E. S. Abhilash Shehab Uddin Al Abid Syed Hani Abidi Alemwork Abie Olugbenga Olusola Abiodun Olumide Abiodun Richard Gyan Aboagye Shady Abohashem Hassan Abolhassani Ulric Sena Abonie Nagah M. Abourashed Mohamed Abouzid Dmitry Abramov Lucas Guimarães Abreu Dariush Abtahi Rana Kamal Abu Farha Fuad Hamdi A. Abuadas Aminu Kende Abubakar Bilyaminu Abubakar Eman Abu-Gharbieh Sawsan Abuhammad Ahmad Y. Abuhelwa Hana J. Abukhadijah Niveen M.E. Abu-Rmeileh Salahdein Aburuz Dina Abushanab Raghu Ram Achar Anirudh Balakrishna Acharya Apurba Acharya Ilana N. Ackerman Juan Manuel Acuna Ousman Adal Lisa C. Adams Lawan Hassan Adamu Mesafint Molla Adane Zenaw Debasu Addisu Isaac Yeboah Addo Oluwafemi Atanda Adeagbo Tajudeen Adesanmi Adebisi Isaac Akinkunmi Adedeji David Adedia Kamoru Ademola Adedokun Rufus Adesoji Adedoyin Oluwatobi E. Adegbile Oyelola A. Adegboye Nurudeen A. Adegoke Olumide Thomas Adeleke Isaac Ayodeji Adesina Miracle Ayomikun Adesina Habeeb Omoponle Adewuyi Temitayo Esther Adeyeoluwa Olorunsola Israel Adeyomoye Kishor Adhikari Ripon Kumar Adhikary Usha Adiga Mohd Adnan Qorinah Estiningtyas Sakilah Adnani Prince Owusu Adoma Leticia Akua Adzigbli Hasan Aalruz Roberto Ariel Abeldaño Zuñiga Nasir Abbas Salahdein Aburuz Rizwan Suliankatchi Abdulkader

Publication Name: Lancet

Publication Date: 2025-10-18

Volume: 406

Issue: 10513

Page Range: 1873-1922

Description:

Background For more than three decades, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) has provided a framework to quantify health loss due to diseases, injuries, and associated risk factors. This paper presents GBD 2023 findings on disease and injury burden and risk-attributable health loss, offering a global audit of the state of world health to inform public health priorities. This work captures the evolving landscape of health metrics across age groups, sexes, and locations, while reflecting on the remaining post-COVID-19 challenges to achieving our collective global health ambitions. Methods The GBD 2023 combined analysis estimated years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs) for 375 diseases and injuries, and risk-attributable burden associated with 88 modifiable risk factors. Of the more than 310 000 total data sources used for all GBD 2023 (about 30% of which were new to this estimation round), more than 120 000 sources were used for estimation of disease and injury burden and 59 000 for risk factor estimation, and included vital registration systems, surveys, disease registries, and published scientific literature. Data were analysed using previously established modelling approaches, such as disease modelling meta-regression version 2.1 (DisMod-MR 2.1) and comparative risk assessment methods. Diseases and injuries were categorised into four levels on the basis of the established GBD cause hierarchy, as were risk factors using the GBD risk hierarchy. Estimates stratified by age, sex, location, and year from 1990 to 2023 were focused on disease-specific time trends over the 2010–23 period and presented as counts (to three significant figures) and age-standardised rates per 100 000 person-years (to one decimal place). For each measure, 95% uncertainty intervals [UIs] were calculated with the 2·5th and 97·5th percentile ordered values from a 250-draw distribution. Findings Total numbers of global DALYs grew 6·1% (95% UI 4·0–8·1), from 2·64 billion (2·46–2·86) in 2010 to 2·80 billion (2·57–3·08) in 2023, but age-standardised DALY rates, which account for population growth and ageing, decreased by 12·6% (11·0–14·1), revealing large long-term health improvements. Non-communicable diseases (NCDs) contributed 1·45 billion (1·31–1·61) global DALYs in 2010, increasing to 1·80 billion (1·63–2·03) in 2023, alongside a concurrent 4·1% (1·9–6·3) reduction in age-standardised rates. Based on DALY counts, the leading level 3 NCDs in 2023 were ischaemic heart disease (193 million [176–209] DALYs), stroke (157 million [141–172]), and diabetes (90·2 million [75·2–107]), with the largest increases in age-standardised rates since 2010 occurring for anxiety disorders (62·8% [34·0–107·5]), depressive disorders (26·3% [11·6–42·9]), and diabetes (14·9% [7·5–25·6]). Remarkable health gains were made for communicable, maternal, neonatal, and nutritional (CMNN) diseases, with DALYs falling from 874 million (837–917) in 2010 to 681 million (642–736) in 2023, and a 25·8% (22·6–28·7) reduction in age-standardised DALY rates. During the COVID-19 pandemic, DALYs due to CMNN diseases rose but returned to pre-pandemic levels by 2023. From 2010 to 2023, decreases in age-standardised rates for CMNN diseases were led by rate decreases of 49·1% (32·7–61·0) for diarrhoeal diseases, 42·9% (38·0–48·0) for HIV/AIDS, and 42·2% (23·6–56·6) for tuberculosis. Neonatal disorders and lower respiratory infections remained the leading level 3 CMNN causes globally in 2023, although both showed notable rate decreases from 2010, declining by 16·5% (10·6–22·0) and 24·8% (7·4–36·7), respectively. Injury-related age-standardised DALY rates decreased by 15·6% (10·7–19·8) over the same period. Differences in burden due to NCDs, CMNN diseases, and injuries persisted across age, sex, time, and location. Based on our risk analysis, nearly 50% (1·27 billion [1·18–1·38]) of the roughly 2·80 billion total global DALYs in 2023 were attributable to the 88 risk factors analysed in GBD. Globally, the five level 3 risk factors contributing the highest proportion of risk-attributable DALYs were high systolic blood pressure (SBP), particulate matter pollution, high fasting plasma glucose (FPG), smoking, and low birthweight and short gestation—with high SBP accounting for 8·4% (6·9–10·0) of total DALYs. Of the three overarching level 1 GBD risk factor categories—behavioural, metabolic, and environmental and occupational—risk-attributable DALYs rose between 2010 and 2023 only for metabolic risks, increasing by 30·7% (24·8–37·3); however, age-standardised DALY rates attributable to metabolic risks decreased by 6·7% (2·0–11·0) over the same period. For all but three of the 25 leading level 3 risk factors, age-standardised rates dropped between 2010 and 2023—eg, declining by 54·4% (38·7–65·3) for unsafe sanitation, 50·5% (33·3–63·1) for unsafe water source, and 45·2% (25·6–72·0) for no access to handwashing facility, and by 44·9% (37·3–53·5) for child growth failure. The three leading level 3 risk factors for which age-standardised attributable DALY rates rose were high BMI (10·5% [0·1 to 20·9]), drug use (8·4% [2·6 to 15·3]), and high FPG (6·2% [–2·7 to 15·6]; non-significant). Interpretation Our findings underscore the complex and dynamic nature of global health challenges. Since 2010, there have been large decreases in burden due to CMNN diseases and many environmental and behavioural risk factors, juxtaposed with sizeable increases in DALYs attributable to metabolic risk factors and NCDs in growing and ageing populations. This long-observed consequence of the global epidemiological transition was only temporarily interrupted by the COVID-19 pandemic. The substantially decreasing CMNN disease burden, despite the 2008 global financial crisis and pandemic-related disruptions, is one of the greatest collective public health successes known. However, these achievements are at risk of being reversed due to major cuts to development assistance for health globally, the effects of which will hit low-income countries with high burden the hardest. Without sustained investment in evidence-based interventions and policies, progress could stall or reverse, leading to widespread human costs and geopolitical instability. Moreover, the rising NCD burden necessitates intensified efforts to mitigate exposure to leading risk factors—eg, air pollution, smoking, and metabolic risks, such as high SBP, BMI, and FPG—including policies that promote food security, healthier diets, physical activity, and equitable and expanded access to potential treatments, such as GLP-1 receptor agonists. Decisive, coordinated action is needed to address long-standing yet growing health challenges, including depressive and anxiety disorders. Yet this can be only part of the solution. Our response to the NCD syndemic—the complex interaction of multiple health risks, social determinants, and systemic challenges—will define the future landscape of global health. To ensure human wellbeing, economic stability, and social equity, global action to sustain and advance health gains must prioritise reducing disparities by addressing socioeconomic and demographic determinants, ensuring equitable health-care access, tackling malnutrition, strengthening health systems, and improving vaccination coverage. We live in times of great opportunity. Funding Gates Foundation and Bloomberg Philanthropies.

Open Access: Yes

DOI: 10.1016/S0140-6736(25)01637-X

Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023

Mohsen Naghavi Hmwe Hmwe Kyu A. Bhoomadevi Mohammad Amin Aalipour Hasan Aalruz Hazim S. Ababneh Bedru J. Abafita Ukachukwu O. Abaraogu Cristiana Abbafati Madineh Abbasi Faezeh Abbaspour Hedayat Abbastabar Abdallah H.A. Abd Al Magied Samar Abd ElHafeez Ashraf Nabiel Abdalla Mohammed Altigani Abdalla Emad M. Abdallah Barkhad Aden Abdeeq Nadin M.I. Abdel Razeq Ahmed Abdelrahman Abdelgalil Reda Abdel-Hameed Michael Abdelmasseh Mahmoud Abdelnabi Wael M. Abdel-Rahman Arman Abdous Mostafa M. Abdrabou Jeza Muhamad Abdul Aziz Deldar Morad Abdulah Auwal Abdullahi Toufik Abdul-Rahman Habtamu Abebe Getahun Aidin Abedi Armita Abedi Parisa Abedi Asrat Agalu Abejew Roberto Ariel Abeldaño Zuñiga Shehab Uddin Al Abid Syed Hani Abidi Alemwork Abie Olugbenga Olusola Abiodun Richard Gyan Aboagye Shady Abohashem Hassan Abolhassani Ulric Sena Abonie Nagah M. Abourashed Mohamed Abouzid Dmitry Abramov Lucas Guimarães Abreu Dariush Abtahi Rana Kamal Abu Farha Fuad Hamdi A. Abuadas Aminu Kende Abubakar Nermeen Abu-Elala Eman Abu-Gharbieh Sawsan Abuhammad Ahmad Y. Abuhelwa Hana J. Abukhadijah Niveen M.E. Abu-Rmeileh Salahdein Aburuz Dina Abushanab Manfred Mario Kokou Accrombessi Anirudh Balakrishna Acharya Apurba Acharya Ousman Adal Lisa C. Adams Abdu A. Adamu Isaac Yeboah Addo Oluwafemi Atanda Adeagbo Tajudeen Adesanmi Adebisi Isaac Akinkunmi Adedeji Kamoru Ademola Adedokun Oluwatobi E. Adegbile Nurudeen A. Adegoke Olumide Thomas Adeleke Bulcha Guye Adema Bashir Aden Isaac Ayodeji Adesina Miracle Ayomikun Adesina Juliana Bunmi Adetunji Habeeb Omoponle Adewuyi Temitayo Esther Adeyeoluwa Mache Tsadik Adhana Ripon Kumar Adhikary Usha Adiga Tanin Adl Parvar Mohd Adnan Qorinah Estiningtyas Sakilah Adnani Prince Owusu Adoma Leticia Akua Adzigbli David Adzrago Giuseppina Affinito Ahmed M. Afifi Clifford Afoakwah Aanuoluwapo Adeyimika Afolabi Rotimi Felix Afolabi Vlad Adrian Afrăsânie Saira Afzal Gizachew Beykaso Agafari Suneth Buddhika Agampodi Thilini Chanchala Agampodi Samar Abd ElHafeez Jeza Muhamad Abdul Aziz Habtamu Abebe Getahun Tanin Adl Parvar

Publication Name: Lancet

Publication Date: 2025-10-18

Volume: 406

Issue: 10513

Page Range: 1811-1872

Description:

Background Timely and comprehensive analyses of causes of death stratified by age, sex, and location are essential for shaping effective health policies aimed at reducing global mortality. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023 provides cause-specific mortality estimates measured in counts, rates, and years of life lost (YLLs). GBD 2023 aimed to enhance our understanding of the relationship between age and cause of death by quantifying the probability of dying before age 70 years (70q0) and the mean age at death by cause and sex. This study enables comparisons of the impact of causes of death over time, offering a deeper understanding of how these causes affect global populations. Methods GBD 2023 produced estimates for 292 causes of death disaggregated by age-sex-location-year in 204 countries and territories and 660 subnational locations for each year from 1990 until 2023. We used a modelling tool developed for GBD, the Cause of Death Ensemble model (CODEm), to estimate cause-specific death rates for most causes. We computed YLLs as the product of the number of deaths for each cause-age-sex-location-year and the standard life expectancy at each age. Probability of death was calculated as the chance of dying from a given cause in a specific age period, for a specific population. Mean age at death was calculated by first assigning the midpoint age of each age group for every death, followed by computing the mean of all midpoint ages across all deaths attributed to a given cause. We used GBD death estimates to calculate the observed mean age at death and to model the expected mean age across causes, sexes, years, and locations. The expected mean age reflects the expected mean age at death for individuals within a population, based on global mortality rates and the population's age structure. Comparatively, the observed mean age represents the actual mean age at death, influenced by all factors unique to a location-specific population, including its age structure. As part of the modelling process, uncertainty intervals (UIs) were generated using the 2·5th and 97·5th percentiles from a 250-draw distribution for each metric. Findings are reported as counts and age-standardised rates. Methodological improvements for cause-of-death estimates in GBD 2023 include a correction for the misclassification of deaths due to COVID-19, updates to the method used to estimate COVID-19, and updates to the CODEm modelling framework. This analysis used 55 761 data sources, including vital registration and verbal autopsy data as well as data from surveys, censuses, surveillance systems, and cancer registries, among others. For GBD 2023, there were 312 new country-years of vital registration cause-of-death data, 3 country-years of surveillance data, 51 country-years of verbal autopsy data, and 144 country-years of other data types that were added to those used in previous GBD rounds. Findings The initial years of the COVID-19 pandemic caused shifts in long-standing rankings of the leading causes of global deaths: it ranked as the number one age-standardised cause of death at Level 3 of the GBD cause classification hierarchy in 2021. By 2023, COVID-19 dropped to the 20th place among the leading global causes, returning the rankings of the leading two causes to those typical across the time series (ie, ischaemic heart disease and stroke). While ischaemic heart disease and stroke persist as leading causes of death, there has been progress in reducing their age-standardised mortality rates globally. Four other leading causes have also shown large declines in global age-standardised mortality rates across the study period: diarrhoeal diseases, tuberculosis, stomach cancer, and measles. Other causes of death showed disparate patterns between sexes, notably for deaths from conflict and terrorism in some locations. A large reduction in age-standardised rates of YLLs occurred for neonatal disorders. Despite this, neonatal disorders remained the leading cause of global YLLs over the period studied, except in 2021, when COVID-19 was temporarily the leading cause. Compared to 1990, there has been a considerable reduction in total YLLs in many vaccine-preventable diseases, most notably diphtheria, pertussis, tetanus, and measles. In addition, this study quantified the mean age at death for all-cause mortality and cause-specific mortality and found noticeable variation by sex and location. The global all-cause mean age at death increased from 46·8 years (95% UI 46·6–47·0) in 1990 to 63·4 years (63·1–63·7) in 2023. For males, mean age increased from 45·4 years (45·1–45·7) to 61·2 years (60·7–61·6), and for females it increased from 48·5 years (48·1–48·8) to 65·9 years (65·5–66·3), from 1990 to 2023. The highest all-cause mean age at death in 2023 was found in the high-income super-region, where the mean age for females reached 80·9 years (80·9–81·0) and for males 74·8 years (74·8–74·9). By comparison, the lowest all-cause mean age at death occurred in sub-Saharan Africa, where it was 38·0 years (37·5–38·4) for females and 35·6 years (35·2–35·9) for males in 2023. Lastly, our study found that all-cause 70q0 decreased across each GBD super-region and region from 2000 to 2023, although with large variability between them. For females, we found that 70q0 notably increased from drug use disorders and conflict and terrorism. Leading causes that increased 70q0 for males also included drug use disorders, as well as diabetes. In sub-Saharan Africa, there was an increase in 70q0 for many non-communicable diseases (NCDs). Additionally, the mean age at death from NCDs was lower than the expected mean age at death for this super-region. By comparison, there was an increase in 70q0 for drug use disorders in the high-income super-region, which also had an observed mean age at death lower than the expected value. Interpretation We examined global mortality patterns over the past three decades, highlighting—with enhanced estimation methods—the impacts of major events such as the COVID-19 pandemic, in addition to broader trends such as increasing NCDs in low-income regions that reflect ongoing shifts in the global epidemiological transition. This study also delves into premature mortality patterns, exploring the interplay between age and causes of death and deepening our understanding of where targeted resources could be applied to further reduce preventable sources of mortality. We provide essential insights into global and regional health disparities, identifying locations in need of targeted interventions to address both communicable and non-communicable diseases. There is an ever-present need for strengthened health-care systems that are resilient to future pandemics and the shifting burden of disease, particularly among ageing populations in regions with high mortality rates. Robust estimates of causes of death are increasingly essential to inform health priorities and guide efforts toward achieving global health equity. The need for global collaboration to reduce preventable mortality is more important than ever, as shifting burdens of disease are affecting all nations, albeit at different paces and scales. Funding Gates Foundation.

Open Access: Yes

DOI: 10.1016/S0140-6736(25)01917-8