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Publications - 6674

Examining the Determinants of Pedestrian Safety Risks in the Bangkok Metropolitan Region, Thailand

Publication Name: Sage Open

Publication Date: 2025-10-01

Volume: 15

Issue: 4

Page Range: Unknown

Description:

Transportation systems are complex and multimodal, comprising diverse travel modes that often compete for limited roadway space. However, the diversity of these modes also generates varying levels of exposure and vulnerability, particularly among pedestrians, who represent the most at-risk group of road users. This study investigates the determinants of Pedestrian Safety (PS) within the Bangkok Metropolitan Region (BMR), focusing on behavioral, and environmental risk factors. Data was collected through a structured questionnaire distributed to 1,120 participants who had encountered potentially hazardous situations while walking. Ordinal logistic regression was used to examine the multifaceted influences shaping pedestrian risk behaviors across three user groups: (1) the general pedestrian population, (2) predominant pedestrian mode users, and (3) individuals with prior pedestrian accident experiences. The findings reveal that physical environmental characteristics and perceived behavioral control, particularly the availability and condition of pedestrian-supportive facilities have significant effects on risk-related behaviors. These results highlight the need for a comprehensive and context-sensitive approach to understanding pedestrian risk and for developing targeted interventions and strategic plans aimed at preventing pedestrian-related crashes in rapidly urbanizing environments.

Open Access: Yes

DOI: 10.1177/21582440251398603

Primitive reflexes as behavioral biomarkers of cognitive aging: associations with physical activity and resilience—a pilot study

Publication Name: Frontiers in Aging Neuroscience

Publication Date: 2025-01-01

Volume: 17

Issue: Unknown

Page Range: Unknown

Description:

Introduction: Primitive reflexes (PRs) are brainstem-mediated automatic responses that typically disappear in early life, but may reappear in older age, which may be associated with neurodegenerative processes. But the presence of PRs in cognitively healthy adults has not yet been sufficiently explored. The relationship between PRs and cognitive functioning (COG) may be influenced by modifiable factors such as physical activity (PA) and psychological resilience. This cross-sectional observational pilot study aimed to investigate the mediating and moderating role of physical activity and resilience in the association between primitive reflexes and cognitive functioning in older adults. Methods: A total of 30 older adults (mean age 73.4 ± 6.9 years; 80% female) living in residential care facilities were assessed. PRs were evaluated using standardized neurological protocols, COG was measured with the Mini-Mental State Examination, PA with the Global Physical Activity Questionnaire, and resilience with the Connor–Davidson Resilience Scale. Moderation and mediation models were tested using Hayes’ PROCESS macro, controlling for age and BMI. Results: A higher number of primitive reflexes was strongly associated with lower cognitive functioning [COG (r = −0.904, p < 0.001)]. Physical activity showed a significant mediating effect in this association, indicating that more active older adults exhibited better cognitive performance despite the presence of primitive reflexes. Resilience, although correlated with both cognition and physical activity, did not show a mediating or moderating effect. Discussion: These findings highlight primitive reflexes as potential behavioral biomarkers of cognitive aging, and underscore the importance of physical activity as a protective factor that may buffer against neurocognitive decline.

Open Access: Yes

DOI: 10.3389/fnagi.2025.1687512

Cybersecurity Regulations and Software Resilience: Strengthening Awareness and Societal Stability

Publication Name: Social Sciences

Publication Date: 2025-10-01

Volume: 14

Issue: 10

Page Range: Unknown

Description:

The societal effects of cybersecurity are widely discussed, but it remains less clear how software security regulations specifically contribute to building a resilient society, particularly in relation to Sustainable Development Goals 5 (Gender Equality), 10 (Reduced Inequalities), and 16 (Peace, Justice and Strong Institutions). This study investigates this connection by examining key EU and U.S. strategies through comparative legal analysis, software development (SDLC) case studies, and a normative–sociological lens. Our findings reveal that major regulations—such as the EU’s Cyber Resilience Act and the U.S. SBOM rules—are not merely reactive, but proactively embed resilience as a fundamental mode of operation. This approach structurally reallocates digital risks from users to manufacturers, reframing software security from a matter of compliance to one of social fairness and institutional trust. We conclude that integrating ‘resilience by design’ into technology rules is more than a technical fix; it is a mechanism that makes digital access fairer and better protects vulnerable populations, enabling technology and society to advance cohesively.

Open Access: Yes

DOI: 10.3390/socsci14100578

Dynamic Capabilities and Technological Innovation for Firm Resilience: A Configurational Analysis

Publication Name: Emerging Science Journal

Publication Date: 2025-10-01

Volume: 9

Issue: 5

Page Range: 2292-2317

Description:

Firm resilience is essential to manage response and rapid recovery from disruptive events for a firm. Moreover, there is limited literature that investigates the combined effects of dynamic capability and technological innovation that are interrelated with firm resilience. This study used the dimensions of firm resilience, which were investigated with both necessary condition analysis (NCA) and fuzzy-set Qualitative Comparative Analysis (fsQCA) methods using survey questionnaires from 308 respondents operating in Bangladeshi corporate industries that are currently facing uncertainties due to unforeseen crises. NCA results showed that visibility, market position, and digitalization achieved firm resilience as these antecedents reached the full percentile to achieve an optimal level of outcome. On the contrary, the influence of reserve capacity and big data analytics was not empirically significant for achieving firm resilience. Moreover, fsQCA results appreciated NCA results and showed four solutions that are sufficient for achieving a high level of firm resilience. The study reveals the configurational effects of dynamic capabilities and technological innovation to achieve firm resilience. The results show the necessary effects of configurational relationships that lead to outcomes. The configurational method is applied to identify the combined effects of antecedents that help managers predict high levels of firm resilience in a turbulent environment.

Open Access: Yes

DOI: 10.28991/ESJ-2025-09-05-01

Urgency or waste of time?

Publication Name: Orvosi Hetilap

Publication Date: 2025-01-01

Volume: 166

Issue: 50

Page Range: 1975-1982

Description:

Introduction: Evaluation and management of markedly elevated blood pressure in the emergency department vary widely. Guidelines recommend repeated measurements in a calm setting and structured follow-up, discouraging acute interventions in asymptomatic patients without end-organ damage. Objective: We retrospectively assessed blood pressure changes and laboratory parameters in older hypertensive patients during emergency care. The primary objective was to compare triage and discharge blood pressure and evaluate differences between discharge and prior renal function and electrolyte values. Secondary objectives included describing intravenous cannulation and length of stay. Method: This single-center retrospective study included 158 patients treated in 2024 for primary hypertension in a county hospital emergency department. Triage and discharge blood pressures were compared using paired tests, discharge serum creatinine, estimated glomerular filtration rate, and potassium were compared to values from the previous 6 months. Results: Systolic blood pressure decreased from a median of 190 to 150 mmHg (p<0.001), diastolic from 92 to 80 mmHg (p<0.001). Estimated glomerular filtration rate (63.5 vs. 61.0 mL/min/1.73 m²) and creatinine (81 vs. 83 µmol/L) showed no significant change. Serum potassium declined slightly (−0.15 mmol/L; p = 0.003) without clinical relevance. Intravenous cannula was inserted in 97.5% of patients, median stay was 6.0 hours. Discussion: The observed decline likely reflects proper measurement and observation effects, in the absence of end‑organ damage a non‑invasive, outpatient‑oriented approach appears appropriate. Conclusion: Most older adults presenting with hypertension did not have a true hypertensive emergency. Blood pressure dropped in many cases just by monitoring and without acute organ damage. The emphasis of the treatment should be on the correct measurement of blood pressure, managing the reversible causes, starting oral antihypertensive therapy, and making an outpatient follow-up appointment. Routine invasive interventions are generally not warranted in asymptomatic cases. Orv Hetil. 2025; 166(50): 1975–1982.

Open Access: Yes

DOI: 10.1556/650.2025.33443

Examination of Concrete Canvas under Quasi-Realistic Loading by Computed Tomography

Publication Name: Infrastructures

Publication Date: 2023-02-01

Volume: 8

Issue: 2

Page Range: Unknown

Description:

The current paper concerns the investigation of CC (Concrete Canvas), a unique building material from the GCCM (geosynthetic cementitious composite mat) product group. The material is suitable for trench lining, trench paving, or even military construction activities, while the authors’ purpose is to investigate the application of the material to road and railway substructure improvement. This research was carried out to verify the material’s suitability for transport infrastructure and its beneficial effects. The authors’ previous study reported that the primary measurements were puncture, compression, and the parameters evaluated in four-point bending (laboratory) tests. However, based on the results, finite element modeling was not feasible because the testing of the composite material in a single layer did not provide an accurate indication. For this reason, the material characteristics required for modeling were investigated. A unique, novel testing procedure and assembly were performed, wherein the material was loaded under quasi-realistic conditions with a crushed stone ballast sample and other continuous particle size distribution samples in a closed polyethylene tube. In addition, the deformation of the material following deformed bonding was measured by computed tomography scanning, and the results were evaluated.

Open Access: Yes

DOI: 10.3390/infrastructures8020023

Control Deficits and Compensatory Mechanisms in Individuals with Chronic Ankle Instability During Dual-Task Stair-to-Ground Transition

Publication Name: Bioengineering

Publication Date: 2025-10-01

Volume: 12

Issue: 10

Page Range: Unknown

Description:

(1) Background: Chronic ankle instability (CAI), a common outcome of ankle sprains, involves recurrent sprains, balance deficits, and gait impairments linked to both peripheral and central neuromuscular dysfunction. Dual-task (DT) demands further aggravate postural control, especially during stair descent, a major source of fall-related injuries. Yet the biomechanical mechanisms of stair-to-ground transition in CAI under dual-task conditions remain poorly understood. (2) Methods: Sixty individuals with CAI and age- and sex-matched controls performed stair-to-ground transitions under single- and dual-task conditions. Spatiotemporal gait parameters, center of pressure (COP) metrics, ankle inversion angle, and relative joint work contributions (Ankle%, Knee%, Hip%) were obtained using 3D motion capture, a force plate, and musculoskeletal modeling. Correlation and regression analyses assessed the relationships between ankle contributions, postural stability, and proximal joint compensations. (3) Results: Compared with the controls, the CAI group demonstrated marked control deficits during the single task (ST), characterized by reduced gait speed, increased step width, elevated mediolateral COP root mean square (COP-ml RMS), and abnormal ankle inversion and joint kinematics; these impairments were exacerbated under DT conditions. Individuals with CAI exhibited a significantly reduced ankle plantarflexion moment and energy contribution (Ankle%), accompanied by compensatory increases in knee and hip contributions. Regression analyses indicated that Ankle% significantly predicted COP-ml RMS and gait speed (GS), highlighting the pivotal role of ankle function in maintaining dynamic stability. Furthermore, CAI participants adopted a “posture-first” strategy under DT, with concurrent deterioration in gait and cognitive performance, reflecting strong reliance on attentional resources. (4) Conclusions: CAI involves global control deficits, including distal insufficiency, proximal compensation, and an inefficient energy distribution, which intensify under dual-task conditions. As the ankle is central to lower-limb kinetics, its dysfunction induces widespread instability. Rehabilitation should therefore target coordinated lower-limb training and progressive dual-task integration to improve motor control and dynamic stability.

Open Access: Yes

DOI: 10.3390/bioengineering12101120

Montelukast Improves Urinary Bladder Function After Complete Spinal Cord Injury in Rats

Publication Name: International Journal of Molecular Sciences

Publication Date: 2025-06-01

Volume: 26

Issue: 12

Page Range: Unknown

Description:

Bladder dysfunction is among the most drastic and quality-of-life-reducing conditions after spinal cord injury (SCI). Neuroinflammation in the lower urinary tract (LUT) after SCI could be a key driver of neurogenic bladder dysfunction and tissue fibrosis. Leukotrienes, a group of highly active lipid mediators, are potent inflammatory mediators. Here, we explored the potential of early montelukast (MLK) therapy, a cysteinyl leukotriene receptor 1 antagonist, on LUT function and structure four weeks after severe SCI in rats. Rats (strain Lewis, female, n = 50) received a permanent bladder catheter, followed by a complete T9 spinal cord transection. MLK was given daily, starting on day one post-injury. Bladder and locomotor function were regularly assessed. Bladder tissue was histologically and immunhistochemically analyzed. Post-SCI, MLK concentrations in plasma and cerebrospinal fluid were clinically relevant. MLK improved bladder functionality. MLK had no impact on smooth muscle alignment and uroepithelial integrity at this early SCI time point. This pilot study gave first insights into early, continuous oral MLK treatment with the first promising results of preserved LUT function and possible subsequent improved tissue integrity.

Open Access: Yes

DOI: 10.3390/ijms26125606

Microalgae–bacteria interaction: a catalyst to improve maize (Zea mays L.) growth and soil fertility

Publication Name: Cereal Research Communications

Publication Date: 2025-06-01

Volume: 53

Issue: 2

Page Range: 1037-1049

Description:

Biofertilisers harbouring living organisms hold allure due to their prospective favourable influence on plant growth, coupled with a diminished environmental footprint and cost-effectiveness in contrast to conventional mineral fertilisers. The purpose of the present study was to evaluate the capacity of a specific microalga (MACC-612, Nostoc linckia) biomass and plant growth-promoting bacteria (PGPB) separately and together to improve crop growth and promote soil health. The research used a factorial design within a completely randomised block framework, featuring four replications for three consecutive years across different fields. The experiment utilised three levels of microalga (control, 0.3 g/L of N. linckia, MACC-612, and 1 g/L of N. linckia, MACC-612) and three levels of bacterial strains (control, Azospirillum lipoferum and Pseudomonas fluorescens). The result demonstrated that the use of N. linckia and PGPB separately or jointly as soil treatment resulted in a substantial improvement in chlorophyll, plant biomass, soil humus, and nitrogen, depending on the environmental conditions of the years. The combined use of N. linckia and PGPB results in an improvement in dry leaf weight by 35.6–107.3% at 50 days after sowing (DAS) and 29.6–49.8% at 65 DAS, compared to the control group. Furthermore, the studies show that the synergistic application of N. linckia at 0.3 g/L, in conjunction with A. lipoferum, significantly improved total nitrogen and (NO3 + NO2)-nitrogen, registering increases of 20.7–40% and 27.1–59.2%, respectively, during the study period. The most effective synergistic combination was identified through the application of 0.3 g/L of N. linckia along with A. lipoferum. Hence, application of biofertilisers through synergistic combinations of two or more microorganisms, such as microalgae and bacteria, holds promise in improving crop chlorophyll, growth, and soil nitrogen.

Open Access: Yes

DOI: 10.1007/s42976-024-00558-8